白细胞介素10可保护小鼠免受致死性内毒素血症的侵害。
Interleukin 10 protects mice from lethal endotoxemia.
作者信息
Howard M, Muchamuel T, Andrade S, Menon S
机构信息
DNAX Research Institute, Palo Alto, California 94304.
出版信息
J Exp Med. 1993 Apr 1;177(4):1205-8. doi: 10.1084/jem.177.4.1205.
Abstract
Interleukin 10 (IL-10) decreases production of IL-1, IL-6, and tumor necrosis factor alpha (TNF-alpha) in vitro, and neutralization of IL-10 in mice leads to elevation of the same monokines. We test here whether this monokine-suppressing property of IL-10 confers on it the capacity to protect mice from lipopolysaccharide-induced shock, a monokine-mediated inflammatory reaction. A single injection of 0.5-1 microgram of recombinant murine IL-10 reproducibly protected BALB/c mice from a lethal intraperitoneal injection of endotoxin. This result was obtained whether the IL-10 was administered concurrently with, or 30 min after the injection of endotoxin. The protective effect of IL-10 was reversed by prior injection of neutralizing anti-IL-10 antibodies, and correlated with a substantial decrease in endotoxin-induced TNF-alpha release. These data implicate IL-10 as a candidate for treatment of bacterial sepsis, and more generally as an effective antiinflammatory reagent.
摘要
白细胞介素10（IL-10）在体外可降低IL-1、IL-6和肿瘤坏死因子α（TNF-α）的产生，在小鼠体内中和IL-10会导致相同单核因子水平升高。我们在此测试IL-10的这种单核因子抑制特性是否赋予其保护小鼠免受脂多糖诱导的休克（一种单核因子介导的炎症反应）的能力。单次注射0.5 - 1微克重组鼠IL-10可重复性地保护BALB/c小鼠免受致死剂量的腹腔内注射内毒素。无论IL-10是与内毒素同时注射还是在内毒素注射后30分钟注射，均可获得此结果。IL-10的保护作用可被预先注射的中和抗IL-10抗体逆转，且与内毒素诱导的TNF-α释放的显著减少相关。这些数据表明IL-10是治疗细菌性败血症的候选药物，更广泛地说，是一种有效的抗炎试剂。
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J Exp Med. 1993 Apr 1;177(4):1205-8. doi: 10.1084/jem.177.4.1205.
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Association between protective efficacy of anti-lipopolysaccharide (LPS) antibodies and suppression of LPS-induced tumor necrosis factor alpha and interleukin 6. Comparison of O side chain-specific antibodies with core LPS antibodies.抗脂多糖（LPS）抗体的保护效力与LPS诱导的肿瘤坏死因子α及白细胞介素6抑制之间的关联。O侧链特异性抗体与核心LPS抗体的比较。
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Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.白细胞介素10，一种新型B细胞刺激因子：X染色体连锁免疫缺陷B细胞的无反应性。
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IL-10, a novel growth cofactor for mature and immature T cells.白细胞介素-10，一种成熟和未成熟T细胞的新型生长辅助因子。
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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.白细胞介素10（IL-10）抑制人单核细胞的细胞因子合成：单核细胞产生的IL-10的自身调节作用。
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