Kobe A, Ebrecht A, Fries R
Institute of Anatomy, Physiology and Hygiene of Domestic Animals, University of Bonn, Germany.
J Appl Bacteriol. 1996 Jan;80(1):26-30. doi: 10.1111/j.1365-2672.1996.tb03185.x.
This study describes the influence of apramycin on minimum inhibitory concentrations (MIC) of intestinal Escherichia coli in young broiler chickens, after oral administration of the antibiotic at a dosage equivalent to a prophylactic course of treatment for 10 d. The bacteria were isolated from cloacal swabs and caecal contents. MICs were determined by agar dilution procedures. MIC of apramycin for the investigated strains ranged from 1 microgram ml-1 to 16 micrograms ml-1. Strains obtained from undosed birds mainly had MIC values of 2 micrograms ml-1. MIC values of 8 micrograms ml-1 or more were recorded only among isolates obtained from chickens which had received apramycin. Administration of apramycin resulted in a slight but statistically significant increase in the average MIC. Statistically higher average MICs were recorded among isolates from cloacal swabs 10 d after withdrawal until the end of the experiment. For strains from caecal contents, this was demonstrated only on one sampling occasion, 15 d after withdrawal.
本研究描述了在给幼龄肉鸡口服相当于10天预防性疗程剂量的阿普拉霉素后，该抗生素对肠道大肠杆菌最低抑菌浓度（MIC）的影响。细菌从泄殖腔拭子和盲肠内容物中分离得到。MIC通过琼脂稀释法测定。所研究菌株的阿普拉霉素MIC范围为1微克/毫升至16微克/毫升。从未给药鸡只获得的菌株主要MIC值为2微克/毫升。仅在从接受过阿普拉霉素的鸡只分离出菌株中记录到8微克/毫升或更高的MIC值。阿普拉霉素的给药导致平均MIC略有但具有统计学意义的增加。在停药后10天直至实验结束，从泄殖腔拭子分离出的菌株中记录到统计学上更高的平均MIC。对于来自盲肠内容物的菌株，仅在停药后15天的一次采样中得到证实。
