来自特兰西瓦尼亚风铃草的三萜皂苷。

Triterpenoid saponins from Cephalaria transsylvanica.

作者信息

Kirmizigül S, Anil H, Rose M E

机构信息

Department of Organic Chemistry, Faculty of Science, Ege University, Izmir, Turkey.

出版信息

J Nat Prod. 1996 Apr;59(4):415-8. doi: 10.1021/np960193x.

DOI:10.1021/np960193x

PMID:8699185

Abstract

Two new triterpenoid saponins, transsylvanosides G and H, were isolated from Cephalaria transsylvanica and their structures established as 3-O-[beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->3)-alpha-L- rhamnopyranosyl(1-->2)-beta-D-xylopyranosyl] hederagenin 28-O-[beta-D-glucopyranosyl(1-->4)-beta-D-xylopyranosyl] ester (1) and 3-O-[beta-D-xylopyranosyl(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-beta-D- xylopyranosyl] hederagenin (2), respectively. A novel prosapogenin (3) was obtained on the alkaline hydrolysis of 1 and its structure defined as 3-O-[beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->3)-alpha-L- rhamnopyranosyl(1-->2)-beta-D-xylopyranosyl] hederagenin. The structures of compounds 1-3 were established by spectral and chemical methods.

摘要

从特兰西瓦尼亚风铃草（Cephalaria transsylvanica）中分离出两种新的三萜皂苷，即反式西瓦诺苷G和H，它们的结构分别确定为3 - O - [β - D - 吡喃葡萄糖基(1→4)-β - D - 吡喃葡萄糖基(1→3)-α - L - 鼠李吡喃糖基(1→2)-β - D - 吡喃木糖基]常春藤皂苷元28 - O - [β - D - 吡喃葡萄糖基(1→4)-β - D - 吡喃木糖基]酯（1）和3 - O - [β - D - 吡喃木糖基(1→3)-α - L - 鼠李吡喃糖基-(1→2)-β - D - 吡喃木糖基]常春藤皂苷元（2）。化合物1经碱性水解得到一种新的前皂苷元（3），其结构确定为3 - O - [β - D - 吡喃葡萄糖基(1→4)-β - D - 吡喃葡萄糖基(1→3)-α - L - 鼠李吡喃糖基(1→2)-β - D - 吡喃木糖基]常春藤皂苷元。通过光谱和化学方法确定了化合物1 - 3的结构。