Guttadauria M, Ellman H, Emmanuel G, Kaplan D, Diamond H
Arthritis Rheum. 1977 Jun;20(5):1071-9. doi: 10.1002/art.1780200506.
Pulmonary function tests were performed in 45 patients with scleroderma. Thirteen patients (29%) were found to have restrictive disease, 12 patients (27%) were found to have obstructive disease, and 19 patients (42%) had small airway disease (SAD). Smoking did not seem to be a factor underlying either obstructive or small airway disease in these patients. A low diffusing capacity was most common in patients with restrictive disease and rarely the only abnormality in pulmonary function. SAD was usually found in patients who had normal chest radiographs and no pulmonary symptoms and was often the only abnormality. SAD is therefore an early and sensitive indicator of pulmonary involvement in scleroderma.
对45例硬皮病患者进行了肺功能测试。发现13例患者（29%）患有限制性疾病，12例患者（27%）患有阻塞性疾病，19例患者（42%）患有小气道疾病（SAD）。吸烟似乎不是这些患者阻塞性疾病或小气道疾病的潜在因素。弥散功能降低在限制性疾病患者中最为常见，很少是肺功能的唯一异常。SAD通常见于胸部X线片正常且无肺部症状的患者，且往往是唯一的异常。因此，SAD是硬皮病肺部受累的早期敏感指标。
