Gunnarsson L G, Lygner P E, Veiga-Cabo J, de Pedro-Cuesta J
Department of Occupational Medicine, Orebro Medical Center Hospital, Sweden.
Neuroepidemiology. 1996;15(3):142-52. doi: 10.1159/000109901.
We have tried to find all cases of motor neuron disease (MND) with onset during the study period 1961-1990 in the county of Skaraborg, Sweden, and in this retrospective study we have identified 168 cases, 107 men and 61 women. Fifty percent of them were alive 2 years after onset. The number of MND cases in consecutive 5-year intervals during the study period was shown to be statistically significantly elevated for males in the period 1981-1985 (Knox test disjoint procedure, p = 0.02). During the period 1973-1984, 70 males had onset of MND, corresponding to an average annual incidence of 4 per 100,000 person-years. This epidemic-like cluster was compared to the MND morbidity in a neighbouring county and was shown to be statistically significantly elevated even when the p value was adjusted for multiple comparisons. Agricultural work was significantly more common among the cases compared to the rest of the population.
我们试图找出1961年至1990年研究期间瑞典斯卡罗堡县所有运动神经元病（MND）发病病例，在这项回顾性研究中，我们确定了168例病例，其中男性107例，女性61例。其中50%在发病后2年仍存活。研究期间连续5年间隔的MND病例数显示，1981年至1985年期间男性病例数在统计学上显著增加（诺克斯检验不连续程序，p = 0.02）。1973年至1984年期间，70名男性患MND，相当于每10万人年平均发病率为4例。将这一类似流行的聚集情况与相邻县的MND发病率进行比较，结果显示，即使对p值进行多重比较调整后，其发病率在统计学上仍显著升高。与其他人群相比，农业工作在病例中更为常见。
