Masterton G, Napier I R, Henderson J N, Roberts J E
Br J Vener Dis. 1977 Apr;53(2):126-8. doi: 10.1136/sti.53.2.126.
The accepted modern practice is to treat each sexually transmitted disease with the shortest possible course of treatment consistent with success. In candidal vulvovaginitis, six days is the minimum period that has so far been found to be successful, but we report here a further reduction to three days. Patients were given two clotrimazole pessaries nightly for three consecutive nights; the overall success rate was 89-4% one month after treatment. This compares favourably with the 93% cure rate reported with the six-day course of clotrimazole. With both the long and short courses, patients having their first attack of genital candidosis responded better than those with a history of previous infection. Short courses of clotrimazole treatment are particularly valuable in dealing with uncooperative women who stop treatment at the earliest possible moment. Clinical and laboratory diagnostic pitfalls and their possible influence upon the therapeutic outcome are also discussed.
现代公认的做法是，用与成功治疗相一致的尽可能短的疗程来治疗每一种性传播疾病。在念珠菌性外阴阴道炎中，到目前为止发现最短成功疗程为六天，但我们在此报告可进一步缩短至三天。患者连续三个晚上每晚使用两粒克霉唑阴道栓；治疗后一个月的总体成功率为89.4%。这与报道的克霉唑六天疗程93%的治愈率相比有优势。无论是长疗程还是短疗程，首次发作生殖器念珠菌病的患者比有既往感染史的患者反应更好。短疗程的克霉唑治疗在处理最早可能时刻就停止治疗的不合作女性时特别有价值。本文还讨论了临床和实验室诊断中的陷阱及其对治疗结果可能产生的影响。
