单次应用咪康唑后在阴道分泌物中的持久性。对阴道念珠菌病治疗的意义。
Persistence of miconazole in vaginal secretions after single applications. Implications for the treatment of vaginal candidosis.
作者信息
Odds F C, MacDonald F
出版信息
Br J Vener Dis. 1981 Dec;57(6):400-1. doi: 10.1136/sti.57.6.400.
Abstract
In vaginal secretions from 16 healthy women aged between 20 and 27 years miconazole persisted in biodetectable concentrations for at least 48 hours after insertion of a single miconazole vaginal pessary. This finding casts doubt on cure rates in vaginal candidosis determined soon after the end of treatment and suggests that current treatment courses with imidazole antifungal agents may be longer than their nominal three or five days.
摘要
在16名年龄在20至27岁之间的健康女性的阴道分泌物中，在单次插入咪康唑阴道栓剂后，咪康唑在可生物检测的浓度下持续至少48小时。这一发现对治疗结束后不久确定的阴道念珠菌病治愈率提出了质疑，并表明目前使用咪唑类抗真菌药物的治疗疗程可能比其标称的三天或五天更长。
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