Spechler S J
Department of Medicine, Beth Israel Hospital, Boston, MA 02215, USA.
Semin Gastrointest Dis. 1996 Apr;7(2):51-60.
When the distal esophagus is lined by a segment of columnar epithelium that is abnormal either because it is extensive or because it has intestinal features, the condition is called Barrett's esophagus. Traditionally, Barrett's esophagus has been associated with severe gastroesophageal reflux disease (GERD) and with a high risk for adenocarcinoma. Recently, investigators have shown that short segments of intestinal metaplasia can be found frequently in the distal esophagus of patients who have few signs and symptoms of GERD. For these patients, the risk for carcinogenesis is not clear. This article summarizes the diagnostic and clinical features of Barrett's esophagus and presents an approach to the management of patients with this fascinating disorder.
当食管远端被一段柱状上皮所覆盖，该柱状上皮因范围广泛或具有肠化生特征而异常时，这种情况被称为巴雷特食管。传统上，巴雷特食管与严重的胃食管反流病（GERD）以及腺癌的高风险相关。最近，研究人员发现，在几乎没有GERD体征和症状的患者的食管远端，常常可以发现短段的肠化生。对于这些患者，癌变风险尚不清楚。本文总结了巴雷特食管的诊断和临床特征，并提出了一种针对患有这种迷人病症的患者的管理方法。
