Rojas Poceros G, Viveros-Renteria E, Kably-Ambe A
Servicio de Gineco-obstetricia, American British Cowdray Hospital, México.
Ginecol Obstet Mex. 1996 Feb;64:64-72.
The HELLP syndrome is an English acronym, for describing patients with Pregnancy Induced Hypertension (PIH), who also has hemolysis, elevated hepatic enzymes and low platelets, its presence is associated with a frequency of maternal mortality from 5 to 25% and when it is associated with hepatic rupture it increases to 35% and a perinatal one from 30 to 60%. It is present in 2 to 12% among women with PIH. Its etiology has not been elucidated completely, the base of its pathophysiology is an unbalance in prostanoid metabolism which conduces to generalize vasopasm with the subsequent endothelial damage and platelets activation. Sibaí describes the diagnostic parameters of the syndrome. Its initial treatment is the hemodinamic stabilization of the maternal status and the evaluation of fetal well-being for decide whether immediate delivery is indicated. HELLP appears in the puerperium in 30% of the cases. There are both maternal and perinatal severe complications, and a recurrence risk of a 4 to 27%. We emphasize the importance of early detection of the syndrome which improves maternal-fetal prognosis.
HELLP综合征是一个英文首字母缩写词，用于描述患有妊娠期高血压疾病（PIH）且伴有溶血、肝酶升高和血小板减少的患者。其出现与孕产妇死亡率5%至25%的发生率相关，当与肝破裂相关时，死亡率增至35%，围产儿死亡率为30%至60%。在患有PIH的女性中，其发生率为2%至12%。其病因尚未完全阐明，其病理生理学基础是前列腺素代谢失衡，导致全身血管痉挛，随后出现内皮损伤和血小板激活。西拜描述了该综合征的诊断参数。其初始治疗是稳定孕产妇的血流动力学状态，并评估胎儿健康状况，以决定是否需要立即分娩。30%的病例中HELLP出现在产褥期。存在孕产妇和围产儿严重并发症，复发风险为4%至27%。我们强调早期发现该综合征的重要性，这可改善母婴预后。
