Missov R M, Stolk R P, van der Bom J G, Hofman A, Bots M L, Pols H A, Grobbee D E
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Netherlands.
Diabetes Care. 1996 Feb;19(2):157-9. doi: 10.2337/diacare.19.2.157.
To compare plasma fibrinogen levels across groups of subjects with and without NIDDM with respect to diabetes therapy and to evaluate the influence of metabolic control and other selected factors.
In a cross-sectional study, plasma fibrinogen was measured in 2,971 elderly subjects aged 55 years and older (mean age 70.8 years). This was part of the baseline examination of the Rotterdam Study, a population-based study of chronic diseases in the elderly.
Plasma fibrinogen levels did not differ among subjects with and without NIDDM (2.84 vs. 2.81 milligrams, P = 0.5). After adjustment for age, sex, smoking, BMI, and waist-to-hip ratio, the plasma fibrinogen levels were higher in subjects receiving insulin therapy. In those without diabetes (n = 2,640), with diabetes but not taking antidiabetes medication (n = 196), taking oral medication (n = 99), and taking insulin (n = 36), the age- and sex-adjusted fibrinogen levels were 2.82 (SE 0.01), 2.79 (0.05), 2.79 (0.07), and 3.23 (0.11) milligrams, respectively (P < 0.005). Adjustment for leukocyte count or serum creatinine level did not affect the observed association, while adjustment for fructosamine decreased the differences.
Plasma fibrinogen levels are elevated in insulin-treated NIDDM patients, which may reflect worse metabolic control in this subgroup.
比较有和没有非胰岛素依赖型糖尿病（NIDDM）的受试者组之间血浆纤维蛋白原水平在糖尿病治疗方面的差异，并评估代谢控制及其他选定因素的影响。
在一项横断面研究中，对2971名年龄在55岁及以上（平均年龄70.8岁）的老年受试者测量血浆纤维蛋白原。这是鹿特丹研究基线检查的一部分，该研究是一项基于人群的老年慢性病研究。
有和没有NIDDM的受试者之间血浆纤维蛋白原水平无差异（2.84对2.81毫克，P = 0.5）。在调整年龄、性别、吸烟、体重指数（BMI）和腰臀比后，接受胰岛素治疗的受试者血浆纤维蛋白原水平较高。在无糖尿病者（n = 2640）、有糖尿病但未服用抗糖尿病药物者（n = 196）、服用口服药物者（n = 99）和服用胰岛素者（n = 36）中，年龄和性别调整后的纤维蛋白原水平分别为2.82（标准误0.01）、2.79（0.05）、2.79（0.07）和3.23（0.11）毫克（P < 0.005）。调整白细胞计数或血清肌酐水平不影响观察到的关联，而调整果糖胺则减小了差异。
胰岛素治疗的NIDDM患者血浆纤维蛋白原水平升高，这可能反映了该亚组中较差的代谢控制情况。
