Tayler R, Piper D W
Cancer. 1977 Jun;39(6):2520-3. doi: 10.1002/1097-0142(197706)39:6<2520::aid-cncr2820390632>3.0.co;2-c.
The carcinogenic effect of cigarette smoke on certain organs is well established epidemiologically, but the evidence in relation to gastric carcinoma is inconclusive. The present study reports the effect of cigarette smoke condensate (CSC) on gastric mucosa grown in organ culture and its effect is compared with that of the known gastric carcinogen, N-methyl-N1-nitro-N-nitrosoguanidine (NG). Viability of the cells was assessed by the uptake of labelled glucose and glycine. It was found that, as gauged by lactate and beta-glucuronidase production into the ambient fluid, CSC produced a response typical of malignancy that did not differ from that with NG.
香烟烟雾对某些器官的致癌作用在流行病学上已得到充分证实，但与胃癌相关的证据尚无定论。本研究报告了香烟烟雾浓缩物（CSC）对器官培养中生长的胃黏膜的影响，并将其与已知的胃癌致癌物N-甲基-N'-硝基-N-亚硝基胍（NG）的影响进行了比较。通过标记葡萄糖和甘氨酸的摄取来评估细胞的活力。结果发现，以乳酸和β-葡萄糖醛酸酶分泌到周围液体中的量来衡量，CSC产生了与恶性肿瘤典型的反应，这与NG产生的反应没有差异。
