Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents.
作者信息
Blondelle S E, Pérez-Payá E, Houghten R A
机构信息
Torrey Pines Institute for Molecular Studies, San Diego, California 92121, USA.
出版信息
Antimicrob Agents Chemother. 1996 May;40(5):1067-71. doi: 10.1128/AAC.40.5.1067.
Abstract
摘要
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本文引用的文献
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Polymyxin, colistin and bacitracin.多粘菌素、黏菌素和杆菌肽。
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Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries.通过使用构象定义的组合文库快速鉴定具有增强抗菌活性的化合物。
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Squalamine: an aminosterol antibiotic from the shark.角鲨胺：一种来自鲨鱼的氨基甾醇类抗生素。
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Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions.组合技术在药物发现中的应用。2. 组合有机合成、文库筛选策略及未来方向。
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Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.组合技术在药物发现中的应用。1. 背景与肽组合文库
J Med Chem. 1994 Apr 29;37(9):1233-51. doi: 10.1021/jm00035a001.
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Science. 1994 Apr 15;264(5157):375-82. doi: 10.1126/science.8153624.
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Cell-lytic and antibacterial peptides that act by perturbing the barrier function of membranes: facets of their conformational features, structure-function correlations and membrane-perturbing abilities.
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The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries.
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