Fawcett I W, Taylor A J, Pepys J
Clin Allergy. 1977 Jan;7(1):1-14. doi: 10.1111/j.1365-2222.1977.tb01418.x.
Six workers with a diagnosis of occupational asthma and one with chronic bronchitis were examined for sensitivity to epoxy resin systems and certain of their components. In six cases the chemical agent responsible for their symptoms was identified by careful inhalation challenge testing, simulating their exposure at work and thus providing a precise aetiological diagnosis. In one worker asthma followed exposure to triethylene tetramine fume; four were sensitive to acid anhydrides, three to phthalic acid anhydride as a fume or powder and one to trimellitic anhydride. On worker thought to be sensitive to toluene di-isocyanate gave negative reactions to this and positive reactions to a phthalic acid anhydride epoxy resin and another thought to have asthma from acid anhydride fumes was found to be sensitive only to toluene di-isocyanate. Immediate, non-immediate or combined asthmatic reactions were elicited.
对六名被诊断为职业性哮喘的工人和一名患有慢性支气管炎的工人进行了对环氧树脂体系及其某些成分的敏感性检查。在六个案例中，通过仔细的吸入激发试验确定了导致其症状的化学制剂，模拟他们在工作中的接触情况，从而做出了精确的病因诊断。一名工人在接触三亚乙基四胺烟雾后患上哮喘；四名对酸酐敏感，三名对邻苯二甲酸酐烟雾或粉末敏感，一名对偏苯三酸酐敏感。一名被认为对甲苯二异氰酸酯敏感的工人对此呈阴性反应，而对邻苯二甲酸酐环氧树脂呈阳性反应，另一名被认为因酸酐烟雾而患哮喘的工人被发现仅对甲苯二异氰酸酯敏感。引发了即刻、非即刻或混合性哮喘反应。
