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DLH1 is a functional Candida albicans homologue of the meiosis-specific gene DMC1.DLH1是减数分裂特异性基因DMC1的功能性白色念珠菌同源物。
Genetics. 1996 Jun;143(2):769-76. doi: 10.1093/genetics/143.2.769.
2
DLH1, the Candida albicans homologue of the meiosis-specific DMC1, is not involved in DNA repair but catalyses spontaneous interhomologue recombination and might promote non-crossover events.DLH1是减数分裂特异性DMC1在白色念珠菌中的同源物，它不参与DNA修复，但催化自发的同源重组，可能促进非交叉事件。
Cell Microbiol. 2020 Jan;22(1):e13137. doi: 10.1111/cmi.13137. Epub 2019 Nov 11.
3
DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway.DMC1在酿酒酵母减数分裂途径中发挥作用，该途径在很大程度上独立于RAD51途径。
Genetics. 1997 Oct;147(2):533-44. doi: 10.1093/genetics/147.2.533.
4
Isolation of a LIM15/DMC1 homolog from the basidiomycete Coprinus cinereus and its expression in relation to meiotic chromosome pairing.从担子菌灰盖鬼伞中分离出LIM15/DMC1同源物及其与减数分裂染色体配对相关的表达
Mol Gen Genet. 1999 Dec;262(4-5):781-9. doi: 10.1007/s004380051141.
5
Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination.酿酒酵母RecA同源物RAD51和DMC1在减数分裂重组中具有不同但又相互重叠的作用。
Genes Cells. 1997 Oct;2(10):615-29. doi: 10.1046/j.1365-2443.1997.1480347.x.
6
High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway.高拷贝数抑制由dmc1突变引起的减数分裂停滞：REC114施加早期重组阻滞，而RAD54促进不依赖DMC1的双链断裂修复途径。
Genes Cells. 1999 Aug;4(8):425-44. doi: 10.1046/j.1365-2443.1999.00273.x.
7
Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination.粟酒裂殖酵母的Dmc1在减数分裂重组中发挥作用。
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8
DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression.DMC1：一种大肠杆菌recA的减数分裂特异性酵母同源物，参与重组、联会复合体形成及细胞周期进程。
Cell. 1992 May 1;69(3):439-56. doi: 10.1016/0092-8674(92)90446-j.
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The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis.酵母减数分裂特异性同源重组基因DMC1的小鼠和人类同源基因在减数分裂过程中具有一种共同的独特形式的外显子跳跃转录本。
Nucleic Acids Res. 1996 Feb 1;24(3):470-7. doi: 10.1093/nar/24.3.470.
10
A Ste6p/P-glycoprotein homologue from the asexual yeast Candida albicans transports the a-factor mating pheromone in Saccharomyces cerevisiae.来自无性酵母白色念珠菌的一种Ste6p/P-糖蛋白同源物在酿酒酵母中转运a-因子交配信息素。
Mol Microbiol. 1998 Feb;27(3):587-98. doi: 10.1046/j.1365-2958.1998.00704.x.

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6
Role of the homologous recombination genes RAD51 and RAD59 in the resistance of Candida albicans to UV light, radiomimetic and anti-tumor compounds and oxidizing agents.同源重组基因 RAD51 和 RAD59 在白念珠菌对紫外线、放射模拟物和抗肿瘤化合物以及氧化剂的抗性中的作用。
Fungal Genet Biol. 2010 May;47(5):433-45. doi: 10.1016/j.fgb.2010.02.007. Epub 2010 Mar 3.
7
Fungal meiosis and parasexual reproduction--lessons from pathogenic yeast.真菌减数分裂和准性生殖——来自病原性酵母的启示。
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8
The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains.白色念珠菌中的准性生殖周期为重组菌株的形成提供了一条不同于减数分裂的途径。
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9
CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida species.CaNAT1，一种用于白色念珠菌和其他致病性念珠菌物种转化的异源显性选择标记。
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10
The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis.Xrcc3的拟南芥同源物在减数分裂中起关键作用。
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本文引用的文献

1
Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae.酿酒酵母早期减数分裂上游激活序列的二分结构。
Mol Cell Biol. 1993 Apr;13(4):2172-81. doi: 10.1128/mcb.13.4.2172-2181.1993.
2
Isolation and characterization of a yeast gene that is homologous with a meiosis-specific cDNA from a plant.从植物中分离并鉴定出一个与减数分裂特异性cDNA同源的酵母基因。
Mol Gen Genet. 1993 Feb;237(1-2):225-32. doi: 10.1007/BF00282804.
3
Isogenic strain construction and gene mapping in Candida albicans.白色念珠菌的同基因菌株构建与基因定位
Genetics. 1993 Jul;134(3):717-28. doi: 10.1093/genetics/134.3.717.
4
Sequence of the RAD55 gene of Saccharomyces cerevisiae: similarity of RAD55 to prokaryotic RecA and other RecA-like proteins.酿酒酵母RAD55基因序列：RAD55与原核生物RecA及其他类RecA蛋白的相似性
Gene. 1994 May 3;142(1):103-6. doi: 10.1016/0378-1119(94)90362-x.
5
Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog.通过STE12同源物突变抑制白色念珠菌的菌丝形成。
Science. 1994 Dec 9;266(5191):1723-6. doi: 10.1126/science.7992058.
6
DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA.由RAD51-ssDNA核蛋白丝介导的DNA链交换，其极性与RecA相反。
Cell. 1995 Aug 11;82(3):453-61. doi: 10.1016/0092-8674(95)90434-4.
7
Structural analysis of a recA-like gene in the genome of Arabidopsis thaliana.拟南芥基因组中一个类recA基因的结构分析。
DNA Res. 1995;2(2):89-93. doi: 10.1093/dnares/2.2.89.
8
RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis.RecA同源物Dmc1和Rad51在减数分裂染色体联会之前相互作用，形成多个核复合物。
Cell. 1994 Dec 16;79(6):1081-92. doi: 10.1016/0092-8674(94)90038-8.
9
The yeast MATa1 gene contains two introns.酵母MATa1基因包含两个内含子。
EMBO J. 1984 May;3(5):1061-5. doi: 10.1002/j.1460-2075.1984.tb01927.x.
10
Isolation and characterization of a beta-tubulin gene from Candida albicans.白色念珠菌β-微管蛋白基因的分离与鉴定
Gene. 1988;63(1):53-63. doi: 10.1016/0378-1119(88)90545-8.

DLH1是减数分裂特异性基因DMC1的功能性白色念珠菌同源物。

DLH1 is a functional Candida albicans homologue of the meiosis-specific gene DMC1.

作者信息

Diener A C, Fink G R

机构信息

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142-1479, USA.

出版信息

Genetics. 1996 Jun;143(2):769-76. doi: 10.1093/genetics/143.2.769.

DOI:10.1093/genetics/143.2.769
PMID:8725225
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1207335/
Abstract

DMC1/LIM15 homologue 1 (DLH1), a gene related to meiosis-specific genes, has been isolated from Candida albicans, a fungus thought not to undergo meiosis. The deduced protein sequence of DLH1 contains 74% amino acid identity with Dmc1p from Saccharomyces cerevisiae and 63% with Lim15p from the plant Lilium longiflorum, meiosis-specific homologues of Escherichia coli RecA. Candida DLH1 complements a dmc1/dmc1 null mutant in S. cerevisiae. High copy expression of DLH1 restores both sporulation and meiotic recombination to a Saccharomyces dmc1 delta/dmc1 delta strain. Unlike the DMC1 gene, which is transcribed only in meiotic cells, the heterologous Candida DLH1 gene is transcribed in both vegetative and meiotic cells of S. cerevisiae. Transcription of DLH1 is not detected or induced in C. albicans under conditions that induce DMC1 and meiosis in S. cerevisiae. The presence of an intact homologue of a meiosis-specific gene in C. albicans raises the possibility that this organism has a cryptic meiotic pathway.

摘要

DMC1/LIM15同源物1（DLH1）是一种与减数分裂特异性基因相关的基因，已从白色念珠菌中分离出来，白色念珠菌是一种被认为不会进行减数分裂的真菌。DLH1推导的蛋白质序列与酿酒酵母的Dmc1p有74%的氨基酸同一性，与植物麝香百合的Lim15p有63%的氨基酸同一性，Lim15p是大肠杆菌RecA的减数分裂特异性同源物。白色念珠菌的DLH1可互补酿酒酵母中的dmc1/dmc1缺失突变体。DLH1的高拷贝表达可使酿酒酵母的dmc1Δ/dmc1Δ菌株恢复孢子形成和减数分裂重组。与仅在减数分裂细胞中转录的DMC1基因不同，异源的白色念珠菌DLH1基因在酿酒酵母的营养细胞和减数分裂细胞中均有转录。在酿酒酵母中诱导DMC1和减数分裂的条件下，未检测到白色念珠菌中DLH1的转录，也未诱导其转录。白色念珠菌中存在减数分裂特异性基因的完整同源物，这增加了该生物体具有隐秘减数分裂途径的可能性。