吲哚和（E）-2-己烯醛，多粘菌素对铜绿假单胞菌和大肠杆菌的植物化学增效剂。
Indole and (E)-2-hexenal, phytochemical potentiators of polymyxins against Pseudomonas aeruginosa and Escherichia coli.
作者信息
Kubo A, Lunde C S, Kubo I
机构信息
Department of Environmental Science, Policy and Management, University of California, Berkeley 94720-3112, USA.
出版信息
Antimicrob Agents Chemother. 1996 Jun;40(6):1438-41. doi: 10.1128/AAC.40.6.1438.
Abstract
Combinations of polymyxins and phytochemicals were tested for antimicrobial activity against two gram-negative bacteria. Various degrees of potentiation were found against Pseudomonas aeruginosa and Escherichia coli with (E)-2-hexenal and indole. Three-compound combinations were found to further increase the activity of polymyxin B sulfate and colistin methanesulfonate against both bacteria. Combinations with colistin against P. aeruginosa resulted in the highest degree of potentiation, with a 512-fold increase in colistin antimicrobial activity. These results indicate the potential efficacy of phytochemical combinations with antibiotics to enhance total biological activity.
摘要
测试了多粘菌素与植物化学物质的组合对两种革兰氏阴性菌的抗菌活性。发现（E）-2-己烯醛和吲哚对铜绿假单胞菌和大肠杆菌有不同程度的增效作用。发现三种化合物的组合可进一步提高硫酸多粘菌素B和粘菌素甲磺酸盐对这两种细菌的活性。粘菌素与铜绿假单胞菌的组合产生了最高程度的增效作用，粘菌素的抗菌活性提高了512倍。这些结果表明植物化学物质与抗生素的组合在增强总生物活性方面具有潜在功效。
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