Riggs B L, Hodgson S F, Hoffman D L, Kelly P J, Johnson K A, Taves D
JAMA. 1980 Feb 1;243(5):446-9.
Thirty-six patients with primary osteoporosis were treated for up to six years with sodium fluoride, calcium supplements, and, in 24 patients, vitamin D. Major adverse reactions (synovitis, painful plantar fascial syndrome, recurrent vomiting, or anemia) occurred in 15 patients (42%). New vertebral fractures occurred at a rate of 329 fractures per 1,000 years of observation. Almost half of them occurred during the first year of therapy, and they were only one sixth as frequent in 12 patients who had fluoride-induced increased trabeculation on vertebral roentogenograms. Nevertheless, until long-term safety and antifracture efficacy are better established, this regimen should continue to be restricted to investigational use.
36例原发性骨质疏松症患者接受了氟化钠、钙剂治疗，其中24例还接受了维生素D治疗，治疗时间长达6年。15例患者（42%）出现了主要不良反应（滑膜炎、足底筋膜疼痛综合征、反复呕吐或贫血）。新的椎体骨折发生率为每1000年观察期329例骨折。其中近一半发生在治疗的第一年，在12例椎体X线片显示有氟诱导小梁增加的患者中，其发生率仅为六分之一。然而，在长期安全性和抗骨折疗效得到更好的确立之前，该治疗方案应继续仅限于研究使用。
