使用大分子组装体作为肽和合成疫苗的表达系统。
Use of macromolecular assemblies as expression systems for peptides and synthetic vaccines.
作者信息
Lomonossoff G P, Johnson J E
机构信息
Department of Virus Research, John Innes Centre, Norwich, UK.
出版信息
Curr Opin Struct Biol. 1996 Apr;6(2):176-82. doi: 10.1016/s0959-440x(96)80072-8.
Abstract
The past decade has witnessed the development of numerous systems for the presentation of antigens on the surface of self-assembling macromolecules. Although the sites for insertion were initially chosen empirically, the determination of the three-dimensional structures of a number of carrier macromolecules has enabled structure-based insertional mutagenesis to be used increasingly. Furthermore, it is now feasible to determine the structure of an inserted sequence as presented in a heterologous environment, making it possible to correlate the detailed structure of a peptide with its immunological properties.
摘要
在过去十年中，出现了许多用于在自组装大分子表面呈递抗原的系统。尽管最初插入位点是凭经验选择的，但对一些载体大分子三维结构的确定使得基于结构的插入诱变越来越多地得到应用。此外，现在确定在异源环境中呈现的插入序列的结构是可行的，这使得将肽的详细结构与其免疫特性联系起来成为可能。
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