Chick J, Erickson C K
Alcohol Problems Clinic, Outpatient Department, Royal Edinburgh Hospital, Scotland, UK.
Alcohol Clin Exp Res. 1996 Apr;20(2):391-402. doi: 10.1111/j.1530-0277.1996.tb01658.x.
Alcoholism, a major public health problem throughout the world, causes enormous damage to health and quality of life and undermines the well-being of families and society. It is associated with liver disease, cancer, cardiovascular problems, accidental deaths, suicides, and homicides. Because of the internationally recognized severity of this disease, this consensus conference was convened to bring together leading international experts to share ideas with regard to current research in the areas of alcohol dependency and treatment, and to discuss the future directions for the pharmacotherapy of alcoholism. The work presented at this conference points to a substantial evolution in the ability of researchers to understand the mechanism by which alcohol acts on the brain and reinforces the concept that alcoholism is a disease of brain chemistry, with a hereditary predisposition that is triggered by psychological and/or environmental factors that are thus far unidentified. The consensus statements proposed by the participants at the close of the conference highlight the definition, etiology, and prevention of alcoholism, as well as current and potential treatments and recommendations that can be used to guide future pharmacologic research.
酗酒是一个全球性的重大公共卫生问题，对健康和生活质量造成巨大损害，破坏家庭和社会的福祉。它与肝病、癌症、心血管问题、意外死亡、自杀及他杀相关。鉴于这种疾病在国际上公认的严重性，召开了这次共识会议，汇聚国际顶尖专家，分享酒精依赖及治疗领域的当前研究思路，并探讨酗酒药物治疗的未来方向。本次会议展示的研究成果表明，研究人员理解酒精作用于大脑机制的能力有了实质性进展，强化了酗酒是一种脑化学疾病的概念，这种疾病具有遗传易感性，由迄今尚未明确的心理和/或环境因素引发。会议结束时与会者提出的共识声明强调了酗酒的定义、病因和预防，以及当前和潜在的治疗方法和建议，可用于指导未来的药物研究。
