Wang C, Zhang X, Yang F
Affiliated Union Hospital, Fujian Medical College, Fuzhou.
Zhonghua Bing Li Xue Za Zhi. 1995 Dec;24(6):356-8.
The expression of nm23 gene product/NDPK was examined immunohistochemically in resected human colorectal carcinomas using anti-NDPK polyclonal antibody. Of the 103 carcinomas tested, 76.7% (79 cases) showed positive staining of nm23/NDPK in the primary lesions. In patients without regional lymph node metastasis, the positive staining rate (90.5%, 38/42) was significantly higher than that in those with nodal involvement (67.2%, 41/61). Inverse relationships were found between nm23/NDPK expression and tumor invasion or the progression of Dukes' staging. Expression of NDPK was positively associated with longer post-operative survival and the relationship was significant. Therefore, our data indicated that nm23 gene plays an important role in lymph node metastasis and invasion in colorectal carcinomas. The expression of nm23 gene product/NDPK may be a useful tool for prognosis of human colorectal carcinomas.
使用抗NDPK多克隆抗体，通过免疫组织化学方法检测了人结直肠癌切除标本中nm23基因产物/NDPK的表达。在检测的103例癌组织中，76.7%（79例）的原发灶显示nm23/NDPK阳性染色。在无区域淋巴结转移的患者中，阳性染色率（90.5%，38/42）显著高于有淋巴结转移的患者（67.2%，41/61）。发现nm23/NDPK表达与肿瘤浸润或Dukes分期进展呈负相关。NDPK的表达与术后生存期延长呈正相关，且这种关系具有显著性。因此，我们的数据表明nm23基因在结直肠癌的淋巴结转移和浸润中起重要作用。nm23基因产物/NDPK的表达可能是预测人结直肠癌预后的一个有用指标。
