Heys S D, Langlois N, Smith I C, Walker L G, Eremin O
Department of Surgery, Surgical Nutrition and Metabolism Unit, University Medical Buildings, Aberdeen Royal Infirmary, Aberdeen, AB9 2ZD, Scotland, UK.
Oncol Rep. 1998 May-Jun;5(3):735-9. doi: 10.3892/or.5.3.735.
NM23 gene product is a putative metastases suppressor gene which has structural homology to a nucleoside diphosphate kinase. Previous studies examining the relationship between NM23 gene product expression and survival in patients with colorectal cancer have revealed conflicting results. However, no study has focused on young patients with colorectal cancer. This study was carried out to determine if expression of the NM23 gene product was correlated with metastatic potential and survival in young patients (45 years and under) with colorectal cancer. Eighty- one patients with colorectal cancer were studied and the presence of the NM23 gene product (H1) was detected using standard immunohistochemical techniques. NM23 gene product expression did not correlate with tumour stage, lymph node involvement by tumour, presence of distant metastases, extramural vascular invasion or degree of tumour differentiation. Independent risk factors for overall survival were: Dukes' stage (p=0.00001) and extramural vascular invasion (p=0.003). NM23 expression was not an independent prognostic indicator (p=0.55). Therefore, NM23 expression does not correlate with existing indicators of tumour aggressiveness and behaviour nor is it an independent predictor of survival in young patients with colorectal cancer.
NM23基因产物是一种假定的转移抑制基因，与核苷二磷酸激酶具有结构同源性。先前关于NM23基因产物表达与结直肠癌患者生存率之间关系的研究结果相互矛盾。然而，尚无研究聚焦于年轻的结直肠癌患者。本研究旨在确定NM23基因产物的表达是否与45岁及以下年轻结直肠癌患者的转移潜能和生存率相关。对81例结直肠癌患者进行了研究，并使用标准免疫组织化学技术检测NM23基因产物（H1）的存在情况。NM23基因产物的表达与肿瘤分期、肿瘤累及淋巴结、远处转移的存在、壁外血管侵犯或肿瘤分化程度均无相关性。总生存的独立危险因素为：杜克分期（p=0.00001）和壁外血管侵犯（p=0.003）。NM23表达不是一个独立的预后指标（p=0.55）。因此，NM23表达与肿瘤侵袭性和行为的现有指标无关，也不是年轻结直肠癌患者生存的独立预测因素。
