Yang X, Hua Y, Zhang X
General Hospital, Beijing Military Command, PLA.
Zhonghua Zhong Liu Za Zhi. 1996 Jan;18(1):10-2.
The activity of intracellular lactic acid dehydrogenase (LDH) and succinic acid dehydrogenase (SDH) was studied by cytochemistry in BGC-823 gastric carcinoma cell line treated with inosine. Cytoplasmic granules of LDH were found decreased or completely disappeared, while little change of SDH was observed. The tumor cells were decreased in number and became atrophic, especially when the cells were treated with high concentrations of inosine. The results suggest that inosine can play a role in suppressing the activity of intracellular LDH, thus blocking the major source of energy supply of cancer cells.
采用细胞化学方法研究了肌苷处理的BGC-823胃癌细胞系中细胞内乳酸脱氢酶（LDH）和琥珀酸脱氢酶（SDH）的活性。发现LDH的细胞质颗粒减少或完全消失，而SDH变化不大。肿瘤细胞数量减少并萎缩，尤其是在高浓度肌苷处理细胞时。结果表明，肌苷可抑制细胞内LDH的活性，从而阻断癌细胞能量供应的主要来源。
