White K E, Cummings J L
Behavioral Neuroscience Section, West Los Angeles Veterans Affairs Medical Center, CA 90073, USA.
Compr Psychiatry. 1996 May-Jun;37(3):188-95. doi: 10.1016/s0010-440x(96)90035-8.
Psychotic symptoms are prominent in schizophrenia and a frequent neuropsychiatric manifestation of Alzheimer's disease (AD), occurring in approximately 50% of patients affected. The shared psychiatric symptoms suggest common cerebral pathophysiologies. Radiologic and pathologic findings indicate a predilection toward limbic involvement, with structural and atrophic changes of the medical temporal region predominating in both disorders. Neurochemical alterations affecting the dopaminergic/cholinergic axis appear to be central to both schizophrenia and AD. The basic pathologies of the two disorders are different, but they have similarities in the pattern of regional brain dysfunction, biochemical dysfunction, and symptomatology. We represent a selective review of these similarities. Insights drawn from these observations enrich the understanding of each disorder.
精神病性症状在精神分裂症中很突出，也是阿尔茨海默病（AD）常见的神经精神表现，约50%的患者会出现。这些共有的精神症状提示存在共同的大脑病理生理学机制。影像学和病理学研究结果表明，两者均倾向于累及边缘系统，且内侧颞叶区域的结构和萎缩性改变在两种疾病中均占主导。影响多巴胺能/胆碱能轴的神经化学改变似乎在精神分裂症和AD中均起关键作用。这两种疾病的基本病理不同，但在大脑区域功能障碍模式、生化功能障碍及症状学方面存在相似之处。我们对这些相似性进行了选择性综述。从这些观察中获得的见解丰富了对每种疾病的认识。
