Dawson R C, Shengelaia G G, Krisht A F, Bonner G D
Department of Radiology, Emory University, Atlanta, Ga, USA.
AJNR Am J Neuroradiol. 1996 May;17(5):853-8.
To assess the histologic changes produced by platinum microcoils with an inner core of cross-linked bovine collagen in experimentally induced aneurysms in swine, and to assess the feasibility of the system for the delivery of the collagen.
Bilateral pouch aneurysms were created in the side wall of the common carotid artery in seven barnyard pigs. Eight aneurysms were treated with coils designed with an interlocking detachment mechanism: in four of these, the coils had an inner core of collagen; in the other four, the platinum microcoils had a similar design but without the collagen mandrel. The packing density of the coils within the aneurysm was approximately the same for both types of coils. The other six aneurysms were left untreated and served as controls. Angiograms were obtained at the time of treatment (2 weeks after the aneurysms were created) and at 1, 4, and 8 weeks after treatment. All animals were killed 8 weeks after the treatment (10 weeks after the aneurysms were created). Arteries and aneurysms were resected en bloc and fixed for histopathologic study.
The interlocking detachment mechanism worked well. Little difference was noted between the two types of coils in their ability to effect complete aneurysmal thrombosis (three of four aneurysms treated with collagen-core coils and two of four aneurysms treated with conventional coils). The collagen-core coils stimulated new collagen formation in areas proximal to the coils, and more fibroblasts were noted near the collagen-core coils than near the conventional coils.
Local fibroblast proliferation and collagen production were stimulated by heterologous cross-linked collagen embedded in micro-coils in this experimental model. Such biologic stimulation holds promise for improving the endovascular cure rate of aneurysms in humans.
评估具有交联牛胶原蛋白内芯的铂微线圈在猪实验性诱导动脉瘤中产生的组织学变化，并评估该胶原蛋白递送系统的可行性。
在7头家猪的颈总动脉侧壁上制造双侧囊状动脉瘤。8个动脉瘤用设计有联锁脱离机制的线圈进行治疗：其中4个，线圈有胶原蛋白内芯；另外4个，铂微线圈有类似设计但没有胶原蛋白心轴。两种类型的线圈在动脉瘤内的填充密度大致相同。另外6个动脉瘤未治疗作为对照。在治疗时（动脉瘤形成后2周）以及治疗后1、4和8周获得血管造影图像。所有动物在治疗后8周（动脉瘤形成后10周）处死。将动脉和动脉瘤整块切除并固定用于组织病理学研究。
联锁脱离机制运行良好。两种类型的线圈在实现完全动脉瘤血栓形成的能力方面差异不大（用胶原蛋白芯线圈治疗的4个动脉瘤中有3个，用传统线圈治疗的4个动脉瘤中有2个）。胶原蛋白芯线圈刺激了线圈近端区域新的胶原蛋白形成，并且在胶原蛋白芯线圈附近比在传统线圈附近观察到更多的成纤维细胞。
在该实验模型中，嵌入微线圈中的异源交联胶原蛋白刺激了局部成纤维细胞增殖和胶原蛋白产生。这种生物刺激有望提高人类动脉瘤的血管内治愈率。
