Meyerhoff D J, Weiner M W, Fein G
Department of Radiology, University of California, San Francisco, USA.
AJNR Am J Neuroradiol. 1996 May;17(5):973-8.
To evaluate the effects of human immunodeficiency virus (HIV) infection on proton metabolites in brain regions carrying the heaviest HIV load.
We used two-dimensional proton MR spectroscopy with a preselected volume at the level of the third ventricle to measure N-acetyl-aspartate (NAA) and metabolites containing choline (Cho), and creatine (Cr) in the basal ganglia of eight cognitively impaired subjects who were seropositive for HIV and eight control subjects who were seronegative for HIV. Results are expressed as metabolite ratios.
In the thalamus and lenticular nuclei, NAA/Cr was not different between the two groups. NAA/Cho was decreased in both the thalamus and lenticular nuclei of the HIV-positive group compared with the HIV-negative group. Cho/Cr tended to be increased in both the thalamus and lenticular nuclei of the HIV-positive group.
The findings suggest no NAA differences between groups, consistent with negligible neuron loss in the region of the brain that carries the heaviest HIV load. The trends toward increased Cho/Cr are consistent with histopathologic findings of infiltration of subcortical gray matter structures with foamy macrophages, microglia, and lymphocytes, or possibly with gliosis.
评估人类免疫缺陷病毒（HIV）感染对携带最高HIV载量的脑区质子代谢物的影响。
我们对8名认知功能受损的HIV血清阳性受试者和8名HIV血清阴性对照受试者，采用二维质子磁共振波谱技术，在第三脑室水平的预选体积内测量基底节区的N-乙酰天门冬氨酸（NAA）以及含胆碱（Cho）和肌酸（Cr）的代谢物。结果以代谢物比率表示。
在丘脑和豆状核中，两组之间的NAA/Cr无差异。与HIV阴性组相比，HIV阳性组丘脑和豆状核中的NAA/Cho均降低。HIV阳性组丘脑和豆状核中的Cho/Cr均有升高趋势。
研究结果表明两组之间NAA无差异，这与携带最高HIV载量的脑区神经元损失可忽略不计一致。Cho/Cr升高的趋势与组织病理学结果一致，即皮质下灰质结构有泡沫状巨噬细胞、小胶质细胞和淋巴细胞浸润，或可能与胶质增生有关。
