Abel E L
Department of Obstetrics/Gynecology, Wayne State University, Detroit, MI, USA.
Alcohol. 1996 May-Jun;13(3):281-5. doi: 10.1016/0741-8329(95)02056-x.
The effects of alcohol and pregnancy on venous blood pH, gases (pO2, pCO2), bicarbonate (HCO-3), and glucose and lactate were examined in pregnant and nonpregnant female rats using anaerobic analytical methods of blood collection. Baseline measurements were obtained prior to treatment and then at 30 min, 1, 2, and 4 h after gastric intubation with 0, 2, 4, or 6 g/kg of alcohol. Alcohol produced a metabolic acidosis, increases in blood glucose and lactate concentrations, and an increase in blood oxygen concentration. Gestation days 18-19 (0.8 gestation) of pregnancy were associated with a slight alkalosis, a decrease in oxygen concentration, no effect on glucose concentrations, and an increase in lactate concentrations compared with nonpregnancy. The only significant interaction between alcohol and pregnancy occurred for pO2 and O2C, wherein alcohol increased both of these parameters in nonpregnant animals only. These results indicate that the rat's pH response to acute alcohol infusion is unique because alcohol does not produce any significant changes in blood pH in other animal models. This change was similar in both pregnant and nonpregnant animals. Except for changes in blood oxygen content, the pregnant and nonpregnant female rat's response to alcohol were also similar as well.
采用厌氧血液采集分析方法，研究了酒精和妊娠对妊娠及未妊娠雌性大鼠静脉血pH值、气体（pO2、pCO2）、碳酸氢盐（HCO-3）、葡萄糖和乳酸的影响。在处理前以及用0、2、4或6 g/kg酒精进行胃插管后30分钟、1小时、2小时和4小时获取基线测量值。酒精导致代谢性酸中毒、血糖和乳酸浓度升高以及血氧浓度增加。与未妊娠相比，妊娠第18 - 19天（妊娠0.8期）出现轻度碱中毒、氧浓度降低、对葡萄糖浓度无影响以及乳酸浓度增加。酒精与妊娠之间唯一显著的相互作用发生在pO2和O2C方面，其中酒精仅使未妊娠动物的这两个参数增加。这些结果表明，大鼠对急性酒精输注的pH反应是独特的，因为在其他动物模型中酒精不会使血液pH产生任何显著变化。这种变化在妊娠和未妊娠动物中相似。除了血氧含量的变化外，妊娠和未妊娠雌性大鼠对酒精的反应也相似。
