在非洲裔青少年广泛存在的青少年牙周炎病例中，伴放线放线杆菌的高毒性克隆株。
Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin.
作者信息
Haubek D, Poulsen K, Westergaard J, Dahlèn G, Kilian M
机构信息
Department of Oral Biology, University of Aarhus, Denmark.
出版信息
J Clin Microbiol. 1996 Jun;34(6):1576-8. doi: 10.1128/jcm.34.6.1576-1578.1996.
Abstract
The bacterium Actinobacillus actinomycetemcomitans has been implicated in the pathogenesis of juvenile periodontitis as the etiologic agent on the basis of several lines of circumstantial evidence. A matter of extensive debate is whether A. actinomycetemcomitans is an exogenous contagious pathogen or an opportunistic pathogen that resides in the normal oral microflora. Here we show evidence of a single clone of A. actinomycetemcomitans isolated from multiple patients with juvenile periodontitis in members of families of African origin living in geographically widespread areas. The clone is characterized by a 530-bp deletion in the leukotoxin gene operon, resulting in a significantly increased production of leukotoxin.
摘要
伴放线放线杆菌已基于多条间接证据被认为是青少年牙周炎发病机制中的病原体。一个广泛争论的问题是，伴放线放线杆菌是一种外源性传染性病原体，还是一种存在于正常口腔微生物群中的机会致病菌。在此，我们展示了从生活在地理分布广泛地区的非洲裔家庭的多名青少年牙周炎患者中分离出的单个伴放线放线杆菌克隆的证据。该克隆的特征是白细胞毒素基因操纵子中有一个530 bp的缺失，导致白细胞毒素产量显著增加。
相似文献
1
Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin.在非洲裔青少年广泛存在的青少年牙周炎病例中，伴放线放线杆菌的高毒性克隆株。
J Clin Microbiol. 1996 Jun;34(6):1576-8. doi: 10.1128/jcm.34.6.1576-1578.1996.
2
Racial tropism of a highly toxic clone of Actinobacillus actinomycetemcomitans associated with juvenile periodontitis.与青少年牙周炎相关的具核梭杆菌高毒性克隆的种族嗜性。
J Clin Microbiol. 1997 Dec;35(12):3037-42. doi: 10.1128/jcm.35.12.3037-3042.1997.
3
Absence of an especially toxic clone among isolates of Actinobacillus actinomycetemcomitans recovered from army recruits.从新兵中分离出的伴放线放线杆菌菌株中不存在特别有毒的克隆。
Clin Oral Investig. 1999 Dec;3(4):161-7. doi: 10.1007/s007840050096.
4
Detection of a highly toxic clone of Actinobacillus actinomycetemcomitans (JP2) in a Moroccan immigrant family with multiple cases of localized aggressive periodontitis.在一个有多例局限性侵袭性牙周炎的摩洛哥移民家庭中检测到伴放线放线杆菌（JP2）的高毒性克隆。
Int J Paediatr Dent. 2004 Jan;14(1):41-8. doi: 10.1111/j.1365-263x.2004.00518.x.
5
The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, epidemiology and etiological role in aggressive periodontitis.伴放线聚集杆菌的高白细胞毒性JP2克隆株：侵袭性牙周炎的进化方面、流行病学及病因学作用
APMIS Suppl. 2010 Sep(130):1-53. doi: 10.1111/j.1600-0463.2010.02665.x.
6
Relationship between conversion of localized juvenile periodontitis-susceptible children from health to disease and Actinobacillus actinomycetemcomitans leukotoxin promoter structure.局部型青少年牙周炎易感性儿童从健康转变为患病与伴放线放线杆菌白细胞毒素启动子结构之间的关系。
J Periodontol. 1998 Sep;69(9):998-1007. doi: 10.1902/jop.1998.69.9.998.
7
Early-onset periodontitis in Morocco is associated with the highly leukotoxic clone of Actinobacillus actinomycetemcomitans.摩洛哥早发性牙周炎与伴放线放线杆菌的高白细胞毒性克隆有关。
J Dent Res. 2001 Jun;80(6):1580-3. doi: 10.1177/00220345010800062001.
8
Evidence for absence in northern Europe of especially virulent clonal types of Actinobacillus actinomycetemcomitans.在北欧缺乏特别具有毒性的伴放线放线杆菌克隆类型的证据。
J Clin Microbiol. 1995 Feb;33(2):395-401. doi: 10.1128/jcm.33.2.395-401.1995.
9
Differential regulation of the leukotoxin operon in highly leukotoxic and minimally leukotoxic strains of Actinobacillus actinomycetemcomitans.伴放线放线杆菌高白细胞毒素菌株和低白细胞毒素菌株中白细胞毒素操纵子的差异调控
Infect Immun. 1996 Jul;64(7):2724-9. doi: 10.1128/iai.64.7.2724-2729.1996.
10
Clonal diversity of Actinobacillus actinomycetemcomitans isolates from young adults with minimal periodontal disease.来自患有轻度牙周病的年轻成年人的伴放线放线杆菌分离株的克隆多样性。
J Periodontal Res. 1999 May;34(4):179-87. doi: 10.1111/j.1600-0765.1999.tb02240.x.
引用本文的文献
1
Saliva microbiome profiling by full-gene 16S rRNA Oxford Nanopore Technology versus Illumina MiSeq sequencing.采用全基因16S rRNA牛津纳米孔技术与Illumina MiSeq测序对唾液微生物群进行分析
NPJ Biofilms Microbiomes. 2024 Dec 18;10(1):149. doi: 10.1038/s41522-024-00634-1.
2
Grade C Molar-Incisor Pattern Periodontitis in Young Adults: What Have We Learned So Far?年轻成年人中的C级磨牙-切牙型牙周炎：我们目前了解到了什么？
Pathogens. 2024 Jul 12;13(7):580. doi: 10.3390/pathogens13070580.
3
Multivariate Analysis of Individual Bacterial Outer Membrane Vesicles Using Fluorescence Microscopy.使用荧光显微镜对单个细菌外膜囊泡进行多变量分析
Chem Biomed Imaging. 2024 Apr 19;2(5):352-361. doi: 10.1021/cbmi.4c00014. eCollection 2024 May 27.
4
Toxin-triggered liposomes for the controlled release of antibiotics to treat infections associated with the gram-negative bacterium, Aggregatibacter actinomycetemcomitans.毒素触发的脂质体用于控制抗生素的释放，以治疗与革兰氏阴性菌伴放线放线杆菌相关的感染。
Colloids Surf B Biointerfaces. 2024 Jun;238:113870. doi: 10.1016/j.colsurfb.2024.113870. Epub 2024 Mar 21.
5
Heterogeneity of Size and Toxin Distribution in Outer Membrane Vesicles.外膜囊泡大小和毒素分布的异质性。
Toxins (Basel). 2024 Mar 7;16(3):138. doi: 10.3390/toxins16030138.
6
Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research.伴放线聚集杆菌：从基础研究到前沿研究
Adv Exp Med Biol. 2022;1373:45-67. doi: 10.1007/978-3-030-96881-6_3.
7
Prevalence of the JP2 genotype of Aggregatibacter actinomycetemcomitans in the world population: a systematic review.世界人群中伴放线聚集杆菌 JP2 基因型的流行率：系统评价。
Clin Oral Investig. 2022 Mar;26(3):2317-2334. doi: 10.1007/s00784-021-04343-3. Epub 2022 Jan 23.
8
Epigallocatechin gallate alters leukotoxin secretion and Aggregatibacter actinomycetemcomitans virulence.没食子酸表没食子儿茶素酯改变白细胞毒素分泌和伴放线放线杆菌毒力。
J Pharm Pharmacol. 2021 Mar 8;73(4):505-514. doi: 10.1093/jpp/rgaa051.
9
Etiology of aggressive periodontitis in individuals of African descent.非洲裔个体侵袭性牙周炎的病因学。
Jpn Dent Sci Rev. 2021 Nov;57:20-26. doi: 10.1016/j.jdsr.2020.12.001. Epub 2021 Feb 20.
10
Oral Lactobacillus strains reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to Aggregatibacter actinomycetemcomitans subtypes in vitro.口腔乳杆菌菌株可降低体外暴露于伴放线放线杆菌亚型的外周血单个核细胞的细胞毒性和细胞因子释放。
BMC Microbiol. 2020 Sep 11;20(1):279. doi: 10.1186/s12866-020-01959-5.
本文引用的文献
1
Regulation of Actinobacillus actinomycetemcomitans leukotoxin expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strains.伴放线放线杆菌白细胞毒素表达的调控：白细胞毒性和低白细胞毒性菌株启动子区域分析
Infect Immun. 1994 Feb;62(2):501-8. doi: 10.1128/iai.62.2.501-508.1994.
2
Hybridization patterns of Actinobacillus actinomycetemcomitans serotypes a-e detected with an rRNA gene probe.
Oral Microbiol Immunol. 1993 Apr;8(2):111-5. doi: 10.1111/j.1399-302x.1993.tb00555.x.
3
Population structure of Actinobacillus actinomycetemcomitans: a framework for studies of disease-associated properties.伴放线放线杆菌的种群结构：疾病相关特性研究的框架
Microbiology (Reading). 1994 Aug;140 ( Pt 8):2049-60. doi: 10.1099/13500872-140-8-2049.
4
Specific genetic variants of Actinobacillus actinomycetemcomitans correlate with disease and health in a regional population of families with localized juvenile periodontitis.伴放线放线杆菌的特定基因变体与患有局限性青少年牙周炎的区域性家庭群体中的疾病和健康状况相关。
Infect Immun. 1994 Aug;62(8):3058-65. doi: 10.1128/iai.62.8.3058-3065.1994.
5
Identification and characterization of genetic cluster groups of Actinobacillus actinomycetemcomitans isolated from the human oral cavity.从人类口腔分离出的伴放线放线杆菌基因簇群的鉴定与特征分析。
J Clin Microbiol. 1994 Jan;32(1):75-81. doi: 10.1128/jcm.32.1.75-81.1994.
6
Microbial ecology of dental plaque and its significance in health and disease.牙菌斑的微生物生态学及其在健康与疾病中的意义。
Adv Dent Res. 1994 Jul;8(2):263-71. doi: 10.1177/08959374940080022001.
7
Evidence for absence in northern Europe of especially virulent clonal types of Actinobacillus actinomycetemcomitans.在北欧缺乏特别具有毒性的伴放线放线杆菌克隆类型的证据。
J Clin Microbiol. 1995 Feb;33(2):395-401. doi: 10.1128/jcm.33.2.395-401.1995.
8
Prevalence of juvenile periodontitis in a British school population.英国学校人群中青少年牙周炎的患病率。
Community Dent Oral Epidemiol. 1984 Jun;12(3):185-7. doi: 10.1111/j.1600-0528.1984.tb01435.x.
9
Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction.人类牙周病中的黑色普氏菌属、二氧化碳嗜纤维菌属和伴放线放线杆菌：定植、存活及组织破坏中的毒力因子
J Dent Res. 1984 Mar;63(3):412-21. doi: 10.1177/00220345840630031101.
10
Actinobacillus actinomycetemcomitans in human periodontal disease. Prevalence in patient groups and distribution of biotypes and serotypes within families.伴放线放线杆菌与人类牙周病。患者群体中的患病率以及家庭内生物型和血清型的分布。
J Periodontol. 1983 Dec;54(12):707-11. doi: 10.1902/jop.1983.54.12.707.
Zotero 插件