Haubek D, Poulsen K, Westergaard J, Dahlèn G, Kilian M
Department of Oral Biology, University of Aarhus, Denmark.
J Clin Microbiol. 1996 Jun;34(6):1576-8. doi: 10.1128/jcm.34.6.1576-1578.1996.
The bacterium Actinobacillus actinomycetemcomitans has been implicated in the pathogenesis of juvenile periodontitis as the etiologic agent on the basis of several lines of circumstantial evidence. A matter of extensive debate is whether A. actinomycetemcomitans is an exogenous contagious pathogen or an opportunistic pathogen that resides in the normal oral microflora. Here we show evidence of a single clone of A. actinomycetemcomitans isolated from multiple patients with juvenile periodontitis in members of families of African origin living in geographically widespread areas. The clone is characterized by a 530-bp deletion in the leukotoxin gene operon, resulting in a significantly increased production of leukotoxin.
伴放线放线杆菌已基于多条间接证据被认为是青少年牙周炎发病机制中的病原体。一个广泛争论的问题是，伴放线放线杆菌是一种外源性传染性病原体，还是一种存在于正常口腔微生物群中的机会致病菌。在此，我们展示了从生活在地理分布广泛地区的非洲裔家庭的多名青少年牙周炎患者中分离出的单个伴放线放线杆菌克隆的证据。该克隆的特征是白细胞毒素基因操纵子中有一个530 bp的缺失，导致白细胞毒素产量显著增加。
