Joó F
Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
Prog Neurobiol. 1996 Feb;48(3):255-73. doi: 10.1016/0301-0082(95)00046-1.
The cerebral endothelium represents an active interface between blood and central nervous system. The blood-brain barrier restricts the free passage of nutrients, hormones, drugs and cellular elements to the brain. Recent studies performed on freshly isolated cerebral microvessels and cultured endothelial cells of brain capillaries provided a better understanding of the properties and functions of cerebral endothelial cells. This review summarizes the main findings of the in vitro approach in the blood-brain barrier research, describes the common endothelial and unique cerebral features of the brain endothelium, and provides a short overview on how these blood-brain barrier characteristics can be induced in cerebral endothelial cells by the neighbouring cells.
脑内皮是血液与中枢神经系统之间的一个活跃界面。血脑屏障限制营养物质、激素、药物和细胞成分自由进入大脑。最近对新鲜分离的脑微血管和脑毛细血管培养内皮细胞进行的研究，使人们对脑内皮细胞的特性和功能有了更好的了解。本综述总结了血脑屏障研究中体外方法的主要发现，描述了脑内皮细胞常见的内皮特征和独特的脑部特征，并简要概述了邻近细胞如何在脑内皮细胞中诱导这些血脑屏障特征。
