DiPenta Jennifer M, Johnson Julia Green, Murphy Rene J L
Dept. of Biology, Acadia University, Wolfville, NS, Canada.
Can J Appl Physiol. 2004 Aug;29(4):419-43. doi: 10.1139/h04-027.
Consistent reports of the positive relationship between regular physical activity and immunosenescence have generated much excitement in the field of exercise immunology. It is generally accepted that natural killer (NK) cell activity per NK cell decreases with age; decreases in NKCA have been associated with infection and death in the aged. The effects of exercise and training on natural killer cells, components of the innate immune system, have been studied extensively in young people. However, the published research on the elderly population is limited. Generally it has been found that training increases or does not change natural killer cell activity or counts in the elderly. The clinical relevance of these results is yet to be fully explored. In addition, the limitations of these studies on immune function have been many, and studies are often difficult to compare due to differences in their methods and presentation of results.
经常进行体育活动与免疫衰老之间存在正向关系的一致报告，在运动免疫学领域引发了诸多关注。人们普遍认为，每个自然杀伤（NK）细胞的活性会随着年龄增长而下降；自然杀伤细胞活性（NKCA）的降低与老年人的感染及死亡有关。运动和训练对作为先天免疫系统组成部分的自然杀伤细胞的影响，在年轻人中已得到广泛研究。然而，针对老年人群体的已发表研究却很有限。一般而言，研究发现训练会增加或不改变老年人的自然杀伤细胞活性或数量。这些结果的临床相关性尚待充分探索。此外，这些免疫功能研究存在诸多局限性，而且由于研究方法和结果呈现方式的差异，各项研究往往难以进行比较。
