Haas A, Walzl M, Eckhardt M, Walzl B, Faulborn J, Feigl B
Department of Ophthalmology, Karl Franzens University, Graz, Austria.
Ophthalmologica. 1996;210(3):171-4. doi: 10.1159/000310701.
The heparin-induced extracorporeal low-density lipoprotein precipitation (HELP) eliminates selectively fibrinogen, total cholesterol, low-density lipoproteins (LDL) and triglycerides and improves hemorheology. We investigated the hemodynamic changes in 10 patients without ocular diseases performing a video fluorescein angiography after a single HELP procedure measuring the arm-retina time (ART) and the arteriovenous passage time (AVP). Laboratory parameters such as fibrinogen, cholesterol, LDL, triglycerides, red cell transit time, plasma and whole-blood viscosity were determined and retinal circulation was measured immediately before and after the HELP application. All of the laboratory parameters were lowered significantly. The ART was unaffected by the HELP procedure; however, there was a significant AVP reduction from 2.41 +/- 0.49 to 1.97 +/- 0.47 (p < 0.005). These results support the hemorheological and hemodynamic efficiency of the HELP system in microcirculatory diseases.
肝素诱导的体外低密度脂蛋白沉淀法（HELP）可选择性清除纤维蛋白原、总胆固醇、低密度脂蛋白（LDL）和甘油三酯，并改善血液流变学。我们对10例无眼部疾病的患者进行了研究，在单次HELP治疗后进行视频荧光血管造影，测量臂-视网膜时间（ART）和动静脉通过时间（AVP），观察血流动力学变化。测定了纤维蛋白原、胆固醇、LDL、甘油三酯、红细胞通过时间、血浆和全血粘度等实验室参数，并在应用HELP前后立即测量视网膜循环。所有实验室参数均显著降低。ART不受HELP治疗的影响；然而，AVP从2.41±0.49显著降低至1.97±0.47（p<0.005）。这些结果支持了HELP系统在微循环疾病中的血液流变学和血流动力学效果。
