伴有咯血的坏死性类肉瘤样肉芽肿病：病例报告及文献复习。

Necrotizing sarcoid granulomatosis with hemoptysis: a case report and literature review.

机构信息

1Department of Respiratory Diseases, Changhai Hospital, Second Military Medical University, Shanghai, China.

出版信息

Diagn Pathol. 2013 May 13;8:79. doi: 10.1186/1746-1596-8-79.

DOI:10.1186/1746-1596-8-79

PMID:23668482

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3662168/

Abstract

UNLABELLED

We present a case of 39-year-old male with the symptoms of fever, cough, chest pain and bloody phlegm, whose chest CT showed multiple subpleural nodules and inflammatory infiltration. Video-Assisted Thoracic Surgery ( VATS ) for right subplural nodule was performed and confirmed the diagnosis of necrotizing sarcoid granulomatosis. Prednisolone was administered and the symptoms were under control untill the occurrence of intermittent hemoptysis after 10 months. Chest CT and bronchoscope revealed the right lower lobe nodule with intraluminal necrotic tissue in the right lower lobe posterior basal segment respectively. Fatal hemoptysis happened during endobronchial biopsy by flexible bronchoscope forcep. Based on this case, we reviewed the relevant literature and discussed the clinical features, pathological changes and prognosis of the disease.

VIRTUAL SLIDES

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摘要

中文译文：

本研究报道了 1 例 39 岁男性患者，其主要表现为发热、咳嗽、胸痛和咯血，胸部 CT 显示多发性胸膜下结节和炎症浸润。行电视辅助胸腔镜手术（VATS）切除右胸膜下结节，术后病理诊断为坏死性类肉瘤样肉芽肿。给予泼尼松龙治疗后症状得到控制，但 10 个月后出现间歇性咯血。再次行胸部 CT 和支气管镜检查，分别显示右下肺后基底段支气管内有坏死性组织的右下肺结节。在经支气管镜活检钳行支气管内活检时，发生致命性咯血。基于此病例，我们复习了相关文献，并讨论了该病的临床特征、病理变化和预后。

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