Kuhn W, Heye N, Müller T, Kraus P, Klotz P, Friedrich B, Welter F L, Przuntek H
Department of Neurology, St. Josef-Hospital, University of Bochum, Federal Republic of Germany.
J Neural Transm (Vienna). 1996;103(3):349-54. doi: 10.1007/BF01271246.
The Motor Performance Test Series (MPTS) is widely used for treatment control in Parkinson's disease (PD). To elucidate the possible influence of depression on the fine motor skills in PD, 54 patients with idiopathic PD were investigated with the MPTS. 27 patients with major intensity of depression were compared to 27 age and motor disability matched patients with minor symptoms of depression, evaluated by the Zung depression scale. As determined by the subtest aiming, a significant lower ability for precise, quick complex arm-hand movements in depressed Parkinsonian patients was found. This result may be explained partly by motivation deficits in depressed patients with PD. On the other hand impairment of special motor loops including frontal lobe projections to specific thalamic subnuclei or to the caudate nucleus may cause disturbances of the subtest aiming in depressed Parkinsonian patients. On the basis of these findings impaired aiming may be explained by diminished ability for complex, semivoluntary movements in depressive Parkinsonian patients. The influence of psychiatric comorbidity on MPTS subtest aiming has to be considered in further therapy studies using evaluation of motor deficits by MPTS.
运动性能测试系列（MPTS）广泛用于帕金森病（PD）的治疗控制。为了阐明抑郁症对帕金森病精细运动技能的可能影响，我们使用MPTS对54例特发性帕金森病患者进行了调查。通过zung抑郁量表评估，将27例重度抑郁症患者与27例年龄和运动残疾相匹配的轻度抑郁症患者进行了比较。通过子测试目标确定，发现抑郁的帕金森病患者在精确、快速的复杂手臂-手部运动方面的能力明显较低。这一结果部分可以由帕金森病抑郁患者的动机缺陷来解释。另一方面，包括额叶向特定丘脑亚核或尾状核投射的特殊运动环路受损，可能会导致抑郁的帕金森病患者子测试目标出现障碍。基于这些发现，抑郁的帕金森病患者复杂、半自主运动能力下降可能解释了目标受损的原因。在进一步使用MPTS评估运动缺陷的治疗研究中，必须考虑精神共病对MPTS子测试目标的影响。
