糖尿病患者糖化血红蛋白HbA1c衰减情况的观察

Observations on the decay of glycated hemoglobin HbA1c in diabetic patients.

作者信息

Rech M E

机构信息

Department of Metabolic Diseases and Nutrition, Heinrich-Heine-University of Düsseldorf/Germany.

出版信息

Exp Clin Endocrinol Diabetes. 1996;104(2):102-5. doi: 10.1055/s-0029-1211430.

DOI:10.1055/s-0029-1211430

PMID:8740932

Abstract

In 44 diabetic patients, who within 7 days lowered their average glycemia by 140 to 220 mg % and kept it at this level over a mean of 36 days, HbA1c was measured repeatedly by HPLC (normal range 4.2-5.6% of total hemoglobin). Thereby, the maximum decay rate of HbA1c could be observed in vivo as being 0.1% per day which is consistent with previous theoretical considerations by other authors. Some clinical implications that this finding may have for diabetic patients are being discussed.

摘要

在44名糖尿病患者中，他们在7天内将平均血糖水平降低了140至220mg%，并在平均36天的时间内维持在这一水平，通过高效液相色谱法（HPLC）反复测量糖化血红蛋白（HbA1c）（正常范围为总血红蛋白的4.2 - 5.6%）。由此，在体内观察到HbA1c的最大衰减率为每天0.1%，这与其他作者先前的理论考虑一致。正在讨论这一发现可能对糖尿病患者产生的一些临床意义。