Littlewood R, Johnson G, House P
Aust N Z J Ophthalmol. 1996 Feb;24(1):47-51. doi: 10.1111/j.1442-9071.1996.tb01551.x.
To determine the correlation between a group of vision tests in atrophic macular degeneration (AMD) in an office setting.
Patients with documented vision loss from atrophic macular degeneration in one eye were invited to attend an eye clinic every three months for a series of six vision tests for their good eye followed by fundus photography. Modified contrast sensitivity, blue/yellow anomaloscopy, flicker fusion frequency, Amsler grid, and photostress recovery time were correlated with Snellen acuity using the Pearson correlation coefficient. The regression of the Snellen acuity on sex, age and the presence of disciform macular degeneration in the other eye was obtained using a general linear model.
The correlation with Snellen acuity result was low for all tests. It was highest for Amsler grid abnormality (r = -0.33345) and blue/yellow anomaloscopy matching range (r = -0.20742), where r denotes the correlation coefficient. Patient age was strongly correlated with Snellen results (P = 0.0001), but it was not significantly related to sex (P = 0.1187) or the presence of disciform macular degeneration in the other eye (P = 0.9989). The photostress recovery time showed enormous inter-visit variations and poor correlation with Snellen acuity (P = 0.0526).
The course of AMD is routinely assessed by Snellen acuity and any of several additional tests. When employing a test battery in an office setting, a clinician needs to know the relative utility and correlation between the tests at his disposal. Of the tests used in this study, the Amsler grid was the most useful addition to the Snellen acuity at all stages of atrophic macular degeneration, and blue/yellow anomaloscopy was useful only in mild macular degeneration where Snellen acuity was 6/12 or better.
确定在门诊环境下一组视力测试与萎缩性黄斑变性（AMD）之间的相关性。
邀请单眼因萎缩性黄斑变性而有视力丧失记录的患者每三个月到眼科诊所，对其健眼进行一系列六项视力测试，随后进行眼底照相。使用Pearson相关系数将改良对比敏感度、蓝/黄异色觉检查、闪烁融合频率、阿姆斯勒方格表和光应激恢复时间与斯内伦视力表视力进行相关性分析。使用一般线性模型得出斯内伦视力表视力与性别、年龄以及另一只眼是否存在盘状黄斑变性之间的回归关系。
所有测试与斯内伦视力表视力结果的相关性均较低。阿姆斯勒方格表异常（r = -0.33345）和蓝/黄异色觉检查匹配范围（r = -0.20742）的相关性最高，其中r表示相关系数。患者年龄与斯内伦视力结果密切相关（P = 0.0001），但与性别（P = 0.1187）或另一只眼是否存在盘状黄斑变性无显著相关性（P = 0.9989）。光应激恢复时间在不同就诊之间显示出巨大差异，且与斯内伦视力表视力的相关性较差（P = 0.0526）。
AMD的病程通常通过斯内伦视力表视力以及其他几项测试进行评估。在门诊环境中使用一组测试时，临床医生需要了解其可使用的各项测试之间的相对效用和相关性。在本研究中使用的测试中，阿姆斯勒方格表在萎缩性黄斑变性的各个阶段都是对斯内伦视力表视力最有用的补充，而蓝/黄异色觉检查仅在斯内伦视力表视力为6/12或更好的轻度黄斑变性中有用。
