对半抗原同基因和半抗原异基因决定簇具有活性的接触敏感性耐受中的抑制细胞。
Suppressor cells in tolerance to contact sensitivity active against hapten-syngeneic and hapten-allogeneic determinants.
作者信息
Claman H N, Miller S D, Sy M S
出版信息
J Exp Med. 1977 Jul 1;146(1):49-58. doi: 10.1084/jem.146.1.49.
Abstract
Genetic restrictions in generation and expression of hapten-specific suppressor cells for contact sensitivity were found. Dinitrophenol- (DNP) or trinitrophenol-modified mouse spleen cells (SC) induced suppressors in donors able to transfer suppression to normal recipients. When allogeneic DNP-SC were injected into BALB/c mice, cells were generated which were suppressive only in the allogeneic strain providing the DNP-SC. In contrast, when DNP-BALB/c-SC were injected into BALB/c mice, suppressors were generated which were active both in BALB/c and in allogeneic mice (e.g., CBA). This apparent absence of syngeneic major histocompability complex restriction may be explained by cross reactive T-cell receptors which are VH gene products.
摘要
研究发现了对半抗原特异性抑制细胞产生和表达的遗传限制，该抑制细胞用于接触敏感性。二硝基苯酚（DNP）或三硝基苯酚修饰的小鼠脾细胞（SC）在供体中诱导出抑制细胞，这些供体能够将抑制作用传递给正常受体。当将同种异体DNP-SC注射到BALB/c小鼠中时，产生的细胞仅在提供DNP-SC的同种异体品系中具有抑制作用。相反，当将DNP-BALB/c-SC注射到BALB/c小鼠中时，产生的抑制细胞在BALB/c和同种异体小鼠（如CBA）中均具有活性。这种明显缺乏同基因主要组织相容性复合体限制的现象可能由作为VH基因产物的交叉反应性T细胞受体来解释。
相似文献
1
Suppressor cells in tolerance to contact sensitivity active against hapten-syngeneic and hapten-allogeneic determinants.对半抗原同基因和半抗原异基因决定簇具有活性的接触敏感性耐受中的抑制细胞。
J Exp Med. 1977 Jul 1;146(1):49-58. doi: 10.1084/jem.146.1.49.
2
H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization.半抗原修饰的淋巴细胞在对1-氟-2,4-二硝基苯接触致敏的耐受性中诱导抑制性T细胞的H-2限制
J Exp Med. 1977 Apr 1;145(4):1071-6. doi: 10.1084/jem.145.4.1071.
3
Suppressor T-cell mechanisms in contact sensitivity. III. Apparent non-major histocompatibility complex restriction is a result of multiple sets of major histocompatibility complex-specific suppressor T cells induced by syngeneic 2,4-dinitrophenyl-modified lymphoid cells.接触敏感性中的抑制性T细胞机制。III. 明显的非主要组织相容性复合体限制是由同基因2,4-二硝基苯基修饰的淋巴细胞诱导的多组主要组织相容性复合体特异性抑制性T细胞的结果。
J Exp Med. 1979 Sep 19;150(3):676-92. doi: 10.1084/jem.150.3.676.
4
Genetic restrictions for the induction of suppressor T cells by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity. Role of the H-2D region of the major histocompatibility complex.在对1-氟-2,4-二硝基苯接触敏感性的耐受性中，半抗原修饰的淋巴细胞诱导抑制性T细胞的遗传限制。主要组织相容性复合体H-2D区域的作用。
J Exp Med. 1978 Mar 1;147(3):788-99. doi: 10.1084/jem.147.3.788.
5
Re-presentation of the hapten dinitrophenol (DNP) to a DNP-specific T-cell line.将半抗原二硝基苯酚（DNP）再次呈递给针对DNP的T细胞系。
Cell Immunol. 1987 Apr 15;106(1):1-11. doi: 10.1016/0008-8749(87)90144-4.
6
The induction of tolerance to DNFB contact sensitivity by using hapten-modified lymphoid cells. III. Effects of hapten concentration on the ability of MLS-disparate cells to induce rapid unresponsiveness.通过使用半抗原修饰的淋巴细胞诱导对二硝基氟苯接触敏感性的耐受性。III. 半抗原浓度对主要组织相容性复合体（MHC）不相容细胞诱导快速无反应性能力的影响
J Immunol. 1980 Aug;125(2):807-13.
7
8
Desensitization of contact allergy to DNFB in mice. III. Characteristics of immediate desensitization induced by haptenated spleen cells.小鼠对二硝基氟苯接触性过敏的脱敏作用。III. 半抗原化脾细胞诱导的即刻脱敏作用的特征
Cell Immunol. 1986 Apr 1;98(2):279-88. doi: 10.1016/0008-8749(86)90288-1.
9
引用本文的文献
1
Mechanisms of idiotype suppression. IV. Functional neutralization in mixtures of idiotype-specific suppressor and hapten-specific suppressor T cells.独特型抑制的机制。IV. 独特型特异性抑制性T细胞与半抗原特异性抑制性T细胞混合物中的功能中和作用。
J Exp Med. 1981 Sep 1;154(3):809-20. doi: 10.1084/jem.154.3.809.
2
I-J subregion and suppressor signals.I-J亚区与抑制信号。
Surv Immunol Res. 1982;1(1):67-75. doi: 10.1007/BF02918242.
3
Mechanisms of regulation of cell-mediated immunity. VII. Suppressor T cells induced by suboptimal doses of antigen plus an I-J-specific allogeneic effect.细胞介导免疫的调节机制。VII. 次优剂量抗原加I-J特异性同种异体效应诱导的抑制性T细胞。
J Exp Med. 1981 Feb 1;153(2):437-49. doi: 10.1084/jem.153.2.437.
4
Suppressor T-cell mechanisms in contact sensitivity. III. Apparent non-major histocompatibility complex restriction is a result of multiple sets of major histocompatibility complex-specific suppressor T cells induced by syngeneic 2,4-dinitrophenyl-modified lymphoid cells.接触敏感性中的抑制性T细胞机制。III. 明显的非主要组织相容性复合体限制是由同基因2,4-二硝基苯基修饰的淋巴细胞诱导的多组主要组织相容性复合体特异性抑制性T细胞的结果。
J Exp Med. 1979 Sep 19;150(3):676-92. doi: 10.1084/jem.150.3.676.
5
Genetic restrictions for the induction of suppressor T cells by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity. Role of the H-2D region of the major histocompatibility complex.在对1-氟-2,4-二硝基苯接触敏感性的耐受性中，半抗原修饰的淋巴细胞诱导抑制性T细胞的遗传限制。主要组织相容性复合体H-2D区域的作用。
J Exp Med. 1978 Mar 1;147(3):788-99. doi: 10.1084/jem.147.3.788.
本文引用的文献
1
T cell control of antibody production.T细胞对抗体产生的控制。
Contemp Top Immunobiol. 1974;3:1-40. doi: 10.1007/978-1-4684-3045-5_1.
2
Tolerance and contact sensitivity to DNFB in mice. 3. Transfer of tolerance with "suppressor T cells".小鼠对二硝基氟苯的耐受性和接触敏感性。3. 用“抑制性T细胞”转移耐受性
J Immunol. 1974 Oct;113(4):1230-6.
3
Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
J Exp Med. 1973 Nov 1;138(5):1213-29. doi: 10.1084/jem.138.5.1213.
4
5
Role of major histocompatibility complex gene products in delayed-type hypersensitivity.主要组织相容性复合体基因产物在迟发型超敏反应中的作用。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2486-90. doi: 10.1073/pnas.73.7.2486.
6
H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.H-2基因复合体限制小鼠迟发型超敏反应的转移。
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5095-8. doi: 10.1073/pnas.72.12.5095.
7
In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.小鼠对雄性特异性（H-Y）抗原的体外细胞介导免疫反应。
J Exp Med. 1975 Nov 1;142(5):1108-20. doi: 10.1084/jem.142.5.1108.
8
The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.T细胞受体、免疫反应基因及其他组织相容性基因产物的功能与相互关系。
Transplant Rev. 1975;22:175-95. doi: 10.1111/j.1600-065x.1975.tb01559.x.
9
Suppressor T cells in cell-mediated immunity.细胞介导免疫中的抑制性T细胞。
Br Med Bull. 1976 May;32(2):158-64. doi: 10.1093/oxfordjournals.bmb.a071349.
10
H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization.半抗原修饰的淋巴细胞在对1-氟-2,4-二硝基苯接触致敏的耐受性中诱导抑制性T细胞的H-2限制
J Exp Med. 1977 Apr 1;145(4):1071-6. doi: 10.1084/jem.145.4.1071.
Zotero 插件