Simón C, Pellicer A, Polan M L
Instituto Valenciano de Infertilidad, Valencia University School of Medicine, Spain.
Hum Reprod. 1995 Dec;10 Suppl 2:43-54. doi: 10.1093/humrep/10.suppl_2.43.
Nowadays, cytokines and growth factors have become increasingly implicated in embryo implantation. Endometrial function, embryo secretions and embryo-endometrial interactions require a continuous dialogue and synchronism between both partners (endometrium and embryo), not only at the endocrine level but also at the local (paracrine/autocrine) level. This review focuses on the interleukin-1 system as an example of a local regulator in embryo implantation. Evidence demonstrating its presence and relevance to human endometrial physiology and human embryo development is presented. Finally, we show data which suggest the possible role of this cytokine in implantation.
如今，细胞因子和生长因子在胚胎着床中的作用越来越受到关注。子宫内膜功能、胚胎分泌物以及胚胎与子宫内膜的相互作用需要双方（子宫内膜和胚胎）之间持续的对话与同步，这不仅体现在内分泌水平，也体现在局部（旁分泌/自分泌）水平。本综述聚焦于白细胞介素-1系统，作为胚胎着床中局部调节因子的一个例子。文中呈现了证明其存在以及与人类子宫内膜生理和人类胚胎发育相关性的证据。最后，我们展示了表明这种细胞因子在着床中可能作用的数据。
