Nilsson B, Nordström C H
J Neurosurg. 1977 Aug;47(2):274-81. doi: 10.3171/jns.1977.47.2.0274.
The metabolic rate was determined in the rat brain during the immediate concussive response to standardized impact accelerations of 7 and 9 m/sec velocity. In one series, the metabolic state was determined in freeze-clamped cortical and brain-stem tissue 20 seconds after the impact. The metabolic rate was calculated from the rate of energy depletion in the adjacent unclamped tissue during 10 seconds of total ischemia. The freeze-clamping procedure per se was shown to enhance the metabolic rate probably by inducing mechanical excitation. In another series, in situ freezing was used for tissue sampling in the same situation. A 10-second period of heart standstill induced a standardized period of ischemia. During the acute concussive response to impact acceleration at 7 m/sec velocity, there was an increase of the metabolic rate in the brain stem. A more intense concussive impact at 9 m/sec velocity further enhanced this reaction and also involved the cortex. It is concluded that the basis of the immediate concussive response is a mechanically elicited neuronal excitation. This may lead to energy depletion unless the increased metabolic demands are met.
在对7米/秒和9米/秒速度的标准化撞击加速度产生的即时震荡反应期间，测定了大鼠大脑的代谢率。在一个系列实验中，在撞击后20秒对冷冻钳夹的皮质和脑干组织的代谢状态进行了测定。代谢率是根据完全缺血10秒期间相邻未钳夹组织中的能量消耗率计算得出的。结果表明，冷冻钳夹操作本身可能通过诱导机械性兴奋提高了代谢率。在另一个系列实验中，在相同情况下采用原位冷冻进行组织采样。心脏停搏10秒可诱导一段标准化的缺血期。在对7米/秒速度的撞击加速度产生的急性震荡反应期间，脑干的代谢率有所增加。9米/秒速度的更强烈震荡撞击进一步增强了这种反应，并且还累及了皮质。得出的结论是，即时震荡反应的基础是机械引发的神经元兴奋。除非增加的代谢需求得到满足，否则这可能导致能量消耗。
