Nilsson B, Pontén U
J Neurosurg. 1977 Aug;47(2):252-61. doi: 10.3171/jns.1977.47.2.0252.
A standardized model of acceleration concussion in the rat was used for the study of cerebral energy metabolism during the acute concussive reaction. Impact velocities of 7 and 9 m/sec were used, and the cerebral metabolic state was determined 1, 4, and 15 minutes after the impact. A concussive response could be sustained with a normal energy state in the tissue, but with the more intense reaction to a 9 m/sec impact, energy depletion usually occurred. At 1 minute these changes were most pronounced in the brain-stem regions. At 4 minutes the reactions were more varied but a progression usually occurred during this time, while at 15 minutes restitution was indicated. Hypoxia due to neurogenic pulmonary edema aggravated the state. The findings are compatible with a high metabolic rate during concussion, but progressive changes indicate the rapid appearance of complicating factors, including hypoxemia and probably also ischemia.
采用标准化的大鼠加速性脑震荡模型来研究急性震荡反应期间的脑能量代谢。使用了7米/秒和9米/秒的撞击速度，并在撞击后1分钟、4分钟和15分钟测定脑代谢状态。在组织能量状态正常的情况下，震荡反应可以持续，但对于9米/秒的撞击产生的更强烈反应，通常会出现能量消耗。在1分钟时，这些变化在脑干区域最为明显。在4分钟时，反应更加多样，但在此期间通常会有进展，而在15分钟时显示有恢复。神经源性肺水肿导致的低氧加重了这种状态。这些发现与脑震荡期间的高代谢率相符，但进行性变化表明包括低氧血症以及可能还有局部缺血在内的复杂因素迅速出现。
