D'Avanzo M, Santinelli R, Tolone C, Bettinelli A, Bianchetti M G
Dipartimento di Pediatria, Seconda Università degli Studi, Naples, Italy.
Pediatr Nephrol. 1995 Dec;9(6):749-50. doi: 10.1007/BF00868731.
A 4.5-year-old boy was admitted to three different hospitals because of a tendency towards dehydration and polyuria, along with normal blood pressure, hypochloraemia, hypokalaemia, metabolic alkalosis and an impaired urinary concentrating ability. A renal biopsy failed to reveal juxtaglomerular hyperplasia. The clinical and laboratory findings failed to improve despite supplementation with potassium chloride and treatment with indomethacin. The urine was found to contain frusemide. The parents denied any drug administration to the boy. The child is now doing well more than 1 year after separation from his mother. Since ingestion of diuretic cannot be differentiated from true Bartter syndrome by blood and urinary electrolyte measurements alone, a diuretic screen is warranted in children with findings consistent with Bartter syndrome.
一名4.5岁男孩因有脱水和多尿倾向，同时伴有血压正常、低氯血症、低钾血症、代谢性碱中毒及尿浓缩能力受损，先后入住三家不同医院。肾活检未发现肾小球旁器增生。尽管补充氯化钾并使用吲哚美辛治疗，临床和实验室检查结果仍未改善。发现尿液中含有速尿。患儿父母否认给孩子服用过任何药物。该患儿与母亲分离1年多后，目前情况良好。由于仅通过血液和尿液电解质测量无法区分利尿剂摄入与真正的巴特综合征，对于临床表现与巴特综合征相符的儿童，有必要进行利尿剂筛查。
