Ihara Y, Mori A, Hayabara T, Kawai M, Namba R, Nobukuni K, Sato K, Kibata M
Department of Neurology, National Minamiokayama Hospital, Okayama, Japan.
J Neurol Sci. 1995 Dec;134(1-2):51-6. doi: 10.1016/0022-510x(95)00193-6.
We studied the relationships between the superoxide dismutase (SOD) activity, free radical (FR) levels and clinical data in patients with sporadic amyotrophic lateral sclerosis (SALS). The SOD activities and blood FR levels of 16 patients with SALS (mean age 58.6 +/- 10.2 years), 11 with other neurological disease, including myotonic dystrophy (ND, mean age 53.5 +/- 9.1 years), and 15 normal control subjects (mean age 56.2 +/- 7.3 years) were measured. The mean levels of FR in blood from the patients with SALS and ND and the SOD activities in red blood cells (RBC) from those with ND were significantly higher than the corresponding control values. There was a positive correlation between the SOD activities in RBC and blood hydroxyl radical levels in the patients with ND, but neither the patients with SALS nor the controls showed such a correlation. The SALS patients without pyramidal signs showed slow disease progression and their mean RBC SOD activity was significantly higher than the corresponding control value. We compared the FR levels and SOD activities of 8 patients who needed a respirator within 40 months after the onset of SALS (SALS40, mean age 58.7 +/- 9.4 years), 3 who needed a respirator over 100 months after the onset of SALS (SALS100, mean age 58.3 +/- 15.9 years) and the controls. The mean blood FR levels of the SALS40 and SALS100 patients were significantly higher than the corresponding control values. The mean SOD activity in RBC from the SALS100 group was significantly higher than the SALS40 and control group values. Therefore, we concluded that elevated blood FR levels do not induce RBC SOD in SALS patients and that the disease progressed more rapidly in SALS patients with low than high RBS SOD activities.
我们研究了散发性肌萎缩侧索硬化症（SALS）患者中超氧化物歧化酶（SOD）活性、自由基（FR）水平与临床数据之间的关系。测量了16例SALS患者（平均年龄58.6±10.2岁）、11例患有其他神经系统疾病（包括强直性肌营养不良，ND，平均年龄53.5±9.1岁）的患者以及15名正常对照者（平均年龄56.2±7.3岁）的SOD活性和血液FR水平。SALS和ND患者血液中的FR平均水平以及ND患者红细胞（RBC）中的SOD活性显著高于相应的对照值。ND患者的RBC中SOD活性与血液羟自由基水平呈正相关，但SALS患者和对照者均未表现出这种相关性。无锥体束征的SALS患者疾病进展缓慢，其RBC SOD平均活性显著高于相应的对照值。我们比较了8例在SALS发病后40个月内需要使用呼吸机的患者（SALS40，平均年龄58.7±9.4岁）、3例在SALS发病后100个月以上需要使用呼吸机的患者（SALS100，平均年龄58.3±15.9岁）以及对照者的FR水平和SOD活性。SALS40和SALS100患者的血液FR平均水平显著高于相应的对照值。SALS100组RBC中的SOD平均活性显著高于SALS40组和对照组的值。因此，我们得出结论，SALS患者血液中升高的FR水平不会诱导RBC SOD，并且RBC SOD活性低的SALS患者比活性高的患者疾病进展更快。
