Wientjes F B, Segal A W
Department of Medicine, University College London, UK.
Semin Cell Biol. 1995 Dec;6(6):357-65. doi: 10.1016/s1043-4682(05)80006-6.
Phagocytic cells possess an electron-transport system which accepts electrons from NADPH in the cytosol to reduce oxygen to the superoxide radical in the vacuolar lumen. The superoxide is instrumental in killing ingested microorganisms. Patients suffering from chronic granulomatous disease (CGD), in which this system is failing, are abnormally susceptible to infectious diseases. Studying CGD patients' neutrophils has been enormously helpful in identifying the components of the superoxide-generating system, known as the NADPH oxidase. This review will describe the components of the electron-transport chain involved in the oxidase and the factors needed for its regulation.
吞噬细胞拥有一个电子传递系统，该系统从细胞质中的NADPH接受电子，以将液泡腔中的氧气还原为超氧阴离子自由基。超氧阴离子在杀死摄入的微生物中起作用。患有慢性肉芽肿病（CGD）的患者，该系统功能失效，异常易患传染病。研究CGD患者的中性粒细胞对于确定产生超氧阴离子的系统（即NADPH氧化酶）的组成成分非常有帮助。本综述将描述氧化酶中涉及的电子传递链的组成成分及其调节所需的因素。
