人类初级视觉皮层功能磁共振成像的线性系统分析
Linear systems analysis of functional magnetic resonance imaging in human V1.
作者信息
Boynton G M, Engel S A, Glover G H, Heeger D J
机构信息
Department of Psychology, Stanford University, California 94305, USA.
出版信息
J Neurosci. 1996 Jul 1;16(13):4207-21. doi: 10.1523/JNEUROSCI.16-13-04207.1996.
The linear transform model of functional magnetic resonance imaging (fMRI) hypothesizes that fMRI responses are proportional to local average neural activity averaged over a period of time. This work reports results from three empirical tests that support this hypothesis. First, fMRI responses in human primary visual cortex (V1) depend separably on stimulus timing and stimulus contrast. Second, responses to long-duration stimuli can be predicted from responses to shorter duration stimuli. Third, the noise in the fMRI data is independent of stimulus contrast and temporal period. Although these tests can not prove the correctness of the linear transform model, they might have been used to reject the model. Because the linear transform model is consistent with our data, we proceeded to estimate the temporal fMRI impulse-response function and the underlying (presumably neural) contrast-response function of human V1.
功能磁共振成像（fMRI）的线性变换模型假设，fMRI反应与一段时间内的局部平均神经活动成正比。这项研究报告了三项实证测试的结果，这些结果支持了这一假设。首先，人类初级视觉皮层（V1）中的fMRI反应分别取决于刺激时间和刺激对比度。其次，对长时间刺激的反应可以从对较短时间刺激的反应中预测出来。第三，fMRI数据中的噪声与刺激对比度和时间段无关。虽然这些测试不能证明线性变换模型的正确性，但它们可能已被用来拒绝该模型。由于线性变换模型与我们的数据一致，我们接着估计了人类V1的fMRI时间脉冲响应函数和潜在的（可能是神经的）对比度响应函数。
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