人类初级视觉皮层功能磁共振成像的线性系统分析
Linear systems analysis of functional magnetic resonance imaging in human V1.
作者信息
Boynton G M, Engel S A, Glover G H, Heeger D J
机构信息
Department of Psychology, Stanford University, California 94305, USA.
出版信息
J Neurosci. 1996 Jul 1;16(13):4207-21. doi: 10.1523/JNEUROSCI.16-13-04207.1996.
Abstract
The linear transform model of functional magnetic resonance imaging (fMRI) hypothesizes that fMRI responses are proportional to local average neural activity averaged over a period of time. This work reports results from three empirical tests that support this hypothesis. First, fMRI responses in human primary visual cortex (V1) depend separably on stimulus timing and stimulus contrast. Second, responses to long-duration stimuli can be predicted from responses to shorter duration stimuli. Third, the noise in the fMRI data is independent of stimulus contrast and temporal period. Although these tests can not prove the correctness of the linear transform model, they might have been used to reject the model. Because the linear transform model is consistent with our data, we proceeded to estimate the temporal fMRI impulse-response function and the underlying (presumably neural) contrast-response function of human V1.
摘要
功能磁共振成像（fMRI）的线性变换模型假设，fMRI反应与一段时间内的局部平均神经活动成正比。这项研究报告了三项实证测试的结果，这些结果支持了这一假设。首先，人类初级视觉皮层（V1）中的fMRI反应分别取决于刺激时间和刺激对比度。其次，对长时间刺激的反应可以从对较短时间刺激的反应中预测出来。第三，fMRI数据中的噪声与刺激对比度和时间段无关。虽然这些测试不能证明线性变换模型的正确性，但它们可能已被用来拒绝该模型。由于线性变换模型与我们的数据一致，我们接着估计了人类V1的fMRI时间脉冲响应函数和潜在的（可能是神经的）对比度响应函数。
相似文献
1
Linear systems analysis of functional magnetic resonance imaging in human V1.人类初级视觉皮层功能磁共振成像的线性系统分析
J Neurosci. 1996 Jul 1;16(13):4207-21. doi: 10.1523/JNEUROSCI.16-13-04207.1996.
2
Integration of EEG source imaging and fMRI during continuous viewing of natural movies.在连续观看自然电影期间，将 EEG 源成像和 fMRI 进行整合。
Magn Reson Imaging. 2010 Oct;28(8):1135-42. doi: 10.1016/j.mri.2010.03.042. Epub 2010 Jun 25.
3
Encoding model of temporal processing in human visual cortex.人类视觉皮层时间处理的编码模型。
Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E11047-E11056. doi: 10.1073/pnas.1704877114. Epub 2017 Dec 5.
4
Nonmonotonic noise tuning of BOLD fMRI signal to natural images in the visual cortex of the anesthetized monkey.麻醉猴视觉皮层中BOLD功能磁共振成像信号对自然图像的非单调噪声调谐
Curr Biol. 2001 Jun 5;11(11):846-54. doi: 10.1016/s0960-9822(01)00242-1.
5
Influence of gradient acoustic noise on fMRI response in the human visual cortex.梯度声学噪声对人类视觉皮层功能磁共振成像反应的影响。
Magn Reson Med. 2005 Aug;54(2):258-63. doi: 10.1002/mrm.20512.
6
Neuronal basis of contrast discrimination.对比度辨别能力的神经元基础。
Vision Res. 1999 Jan;39(2):257-69. doi: 10.1016/s0042-6989(98)00113-8.
7
Orientation-tuned FMRI adaptation in human visual cortex.人类视觉皮层中方向调谐的功能磁共振成像适应
J Neurophysiol. 2005 Dec;94(6):4188-95. doi: 10.1152/jn.00378.2005. Epub 2005 Aug 24.
8
Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging.使用磁共振成像对人类MT及相关视觉皮层区域进行功能分析。
J Neurosci. 1995 Apr;15(4):3215-30. doi: 10.1523/JNEUROSCI.15-04-03215.1995.
9
An investigation of the impulse functions for the nonlinear BOLD response in functional MRI.功能磁共振成像中非线性脑血氧水平依赖反应的脉冲函数研究。
Magn Reson Imaging. 2000 Oct;18(8):931-8. doi: 10.1016/s0730-725x(00)00214-9.
10
The relationship between task performance and functional magnetic resonance imaging response.任务表现与功能磁共振成像反应之间的关系。
J Neurosci. 2005 Mar 23;25(12):3023-31. doi: 10.1523/JNEUROSCI.4476-04.2005.
引用本文的文献
1
Searchlight-based trial-wise fMRI decoding in the presence of trial-by-trial correlations.在存在逐次试验相关性的情况下基于探照灯的逐次试验功能磁共振成像解码
Imaging Neurosci (Camb). 2025 Sep 2;3. doi: 10.1162/IMAG.a.131. eCollection 2025.
2
Revealing layer-specific cortical activity in human M1 using high-resolution line-scanning fMRI.使用高分辨率线扫描功能磁共振成像揭示人类初级运动皮层的层特异性皮质活动。
Imaging Neurosci (Camb). 2025 Feb 21;3. doi: 10.1162/imag_a_00477. eCollection 2025.
3
Detectability and cortical depth dependence of stimulus-driven high-frequency BOLD oscillations in the human primary somatosensory and motor cortex.人类初级体感皮层和运动皮层中刺激驱动的高频血氧水平依赖振荡的可检测性及皮层深度依赖性
Imaging Neurosci (Camb). 2025 Jan 13;3. doi: 10.1162/imag_a_00427. eCollection 2025.
4
Dorso-medial prefrontal cortex responses to social smiles predict sociability in early human development.背内侧前额叶皮层对社交微笑的反应可预测人类早期发育中的社交能力。
Imaging Neurosci (Camb). 2024 Apr 8;2. doi: 10.1162/imag_a_00129. eCollection 2024.
5
A 7T interleaved fMRS and fMRI study on visual contrast dependency in the human brain.一项关于人脑视觉对比度依赖性的7T交错式功能磁共振波谱成像和功能磁共振成像研究。
Imaging Neurosci (Camb). 2023 Nov 17;1. doi: 10.1162/imag_a_00031. eCollection 2023.
6
Combined Auditory, Tactile, and Visual fMRI Reveals Sensory-Biased and Supramodal Working Memory Regions in Human Frontal Cortex.听觉、触觉和视觉功能磁共振成像联合揭示人类额叶皮质中存在感觉偏向和超模态工作记忆区域。
bioRxiv. 2025 Jun 21:2025.06.21.660846. doi: 10.1101/2025.06.21.660846.
7
Minimum-Phase Property of the Hemodynamic Response Function, and Implications for Granger Causality in fMRI.血流动力学响应函数的最小相位特性及其对功能磁共振成像中格兰杰因果关系的影响。
Hum Brain Mapp. 2025 Jul;46(10):e70285. doi: 10.1002/hbm.70285.
8
The diagnostic potential of resting state functional MRI: Statistical concerns.静息态功能磁共振成像的诊断潜力：统计学方面的问题。
Neuroimage. 2025 Aug 15;317:121334. doi: 10.1016/j.neuroimage.2025.121334. Epub 2025 Jun 17.
9
Attention Alters Population Spatial Frequency Tuning.注意力改变群体空间频率调谐。
J Neurosci. 2025 Jun 18;45(25):e0251252025. doi: 10.1523/JNEUROSCI.0251-25.2025.
10
Functional Ultrasound Imaging of Auditory Responses in Comatose Patients.昏迷患者听觉反应的功能超声成像
Research (Wash D C). 2025 May 15;8:0709. doi: 10.34133/research.0709. eCollection 2025.
本文引用的文献
1
Movement-related effects in fMRI time-series.
Magn Reson Med. 1996 Mar;35(3):346-55. doi: 10.1002/mrm.1910350312.
2
Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping.成像光谱学揭示的电活动与皮质微循环之间的相互作用：对功能性脑图谱的意义。
Science. 1996 Apr 26;272(5261):551-4. doi: 10.1126/science.272.5261.551.
3
Forward pattern masking and adaptation: effects of duration, interstimulus interval, contrast, and spatial and temporal frequency.
Vision Res. 1993 May;33(7):959-80. doi: 10.1016/0042-6989(93)90079-c.
4
Processing strategies for time-course data sets in functional MRI of the human brain.人类大脑功能磁共振成像中时程数据集的处理策略
Magn Reson Med. 1993 Aug;30(2):161-73. doi: 10.1002/mrm.1910300204.
5
Modeling simple-cell direction selectivity with normalized, half-squared, linear operators.使用归一化的半平方线性算子对简单细胞方向选择性进行建模。
J Neurophysiol. 1993 Nov;70(5):1885-98. doi: 10.1152/jn.1993.70.5.1885.
6
Summation and division by neurons in primate visual cortex.灵长类动物视觉皮层中神经元的总和与除法运算。
Science. 1994 May 27;264(5163):1333-6. doi: 10.1126/science.8191289.
7
Functional magnetic resonance imaging (FMRI) of the human brain.人类大脑的功能磁共振成像（FMRI）。
J Neurosci Methods. 1994 Oct;54(2):171-87. doi: 10.1016/0165-0270(94)90191-0.
8
BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals.4特斯拉下基于血氧水平依赖性功能磁共振成像包括毛细血管床的贡献：回波平面成像与先前使用内在信号的光学成像相关。
Magn Reson Med. 1995 Mar;33(3):453-9. doi: 10.1002/mrm.1910330323.
9
Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging.使用磁共振成像对人类MT及相关视觉皮层区域进行功能分析。
J Neurosci. 1995 Apr;15(4):3215-30. doi: 10.1523/JNEUROSCI.15-04-03215.1995.
10
Functional MR imaging. Capabilities and limitations.功能磁共振成像。能力与局限。
Neuroimaging Clin N Am. 1995 May;5(2):161-91.
Zotero 插件