Viljoen D, Oosthuizen C, van der Westhuizen S
Department of Human Genetics, University of Cape Town Medical School.
East Afr Med J. 1996 May;73(5):327-9.
A prospective 2-year study involving a questionnaire administered by a Genetic Counsellor was carried out to ascertain patient attitudes to prenatal screening and termination of pregnancy (TOP) at Groote Schuur Hospital. Women were questioned regarding their religious affiliation, education, ethnic group, reason for referral and age. Following ultrasonography, non-directive counselling was given regarding amniocentesis and TOP. Four hundred and sixty six women were investigated of whom 74% were of mixed ancestry, 14% Black and 12% White. Three hundred and sixteen persons were offered amniocentesis (67.8%). Muslim women accepted less frequently (66%) than other religious affiliations (79.7%) (p = 0.025). Overall amniocentesis acceptance was 75.9%. TOP was performed in 45 pregnancies (9.7%). Muslim women accepted TOP 1.33 times (C.I. 0.32-5.6) more frequently than those of other religious persuasions. Overall TOP acceptance rate was 76.3%. The mixed ethnic population of pregnant women seen at Groote Schuur Hospital readily accept prenatal screening and TOP following non-directive genetic counselling. The introduction of prenatal screening programmes for the prevention of severe congenital defects in this population would be successful and cost-effective.
在格罗特·舒尔医院开展了一项为期两年的前瞻性研究，由遗传咨询师进行问卷调查，以确定患者对产前筛查和终止妊娠（TOP）的态度。询问了女性的宗教信仰、教育程度、种族、转诊原因和年龄。超声检查后，就羊膜穿刺术和终止妊娠提供了非指导性咨询。共调查了466名女性，其中74%为混血，14%为黑人，12%为白人。316人接受了羊膜穿刺术（67.8%）。穆斯林女性接受率（66%）低于其他宗教信仰者（79.7%）（p = 0.025）。总体羊膜穿刺术接受率为75.9%。45例妊娠（9.7%）进行了终止妊娠。穆斯林女性接受终止妊娠的频率比其他宗教信仰者高1.33倍（置信区间0.32 - 5.6）。总体终止妊娠接受率为76.3%。在格罗特·舒尔医院就诊的混血孕妇群体在接受非指导性遗传咨询后很容易接受产前筛查和终止妊娠。在该人群中引入预防严重先天性缺陷的产前筛查项目将是成功且具有成本效益的。
