Grandjean P, Weihe P, Needham L L, Burse V W, Patterson D G, Sampson E J, Jørgensen P J, Vahter M
Institute of Community Health, Odense University, Denmark.
Environ Res. 1995 Oct;71(1):29-38. doi: 10.1006/enrs.1995.1064.
Human transition milk was sampled from 88 mothers at the Faroe Islands, where the seafood diet includes pilot whale meat and blubber. Milk mercury concentrations (median, 2.45 micrograms/liter) were significantly associated with mercury concentrations in cord blood and with the frequency of pilot whale dinners during pregnancy. Milk selenium concentrations (mean, 19.1 micrograms/liter) correlated significantly with concentrations in cord blood but not with seafood consumption. Arsenic concentrations were very low. Twenty-four of the milk samples were separated into four pools based on fish intake and milk mercury concentrations. The polychlorinated biphenyl (PCB) concentrations (1.8-3.5 micrograms/g lipid) were high and mainly due to congener numbers 153, 180, and 138. One pool contained a congener 77 concentration of 1380 ppt, which is the highest ever reported in a human specimen for a coplanar PCB. The highest PCB concentrations were seen in the pools from women who had eaten frequent whale dinners and whose milk contained high mercury concentrations. The concentrations of chlorinated dibenzo-p-dioxins and furans were not similarly elevated. Given the advantages associated with breast-feeding, advice to nursing mothers in this population should take into regard the possible risks associated with long-term exposure to milk contaminants.
在法罗群岛，从88名母亲那里采集了人过渡乳，当地的海鲜饮食包括巨头鲸肉和鲸脂。母乳中的汞浓度（中位数为2.45微克/升）与脐血中的汞浓度以及孕期食用巨头鲸晚餐的频率显著相关。母乳中的硒浓度（平均值为19.1微克/升）与脐血中的浓度显著相关，但与海鲜摄入量无关。砷浓度非常低。根据鱼类摄入量和母乳汞浓度，将24份母乳样本分成了4组。多氯联苯（PCB）浓度（1.8 - 3.5微克/克脂质）很高，主要是由于同系物153、180和138。其中一组中同系物77的浓度为1380皮克/万亿，这是在人类样本中报道的共面多氯联苯的最高浓度。在食用巨头鲸晚餐频繁且母乳汞浓度高的女性的分组中，多氯联苯浓度最高。氯化二苯并 - 对 - 二恶英和呋喃的浓度没有类似升高。鉴于母乳喂养的诸多益处，针对该人群的哺乳期母亲的建议应考虑到长期接触母乳污染物可能带来的风险。
