Wang Jian, Dong Wei-Wei, Zhang Wen-Hua, Zheng Jian, Wang Xin
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, The Second People's Hospital of Chengdu, Chengdu, Sichuan, China.
CNS Neurosci Ther. 2014 Aug;20(8):710-6. doi: 10.1111/cns.12288. Epub 2014 Jun 16.
For around two decades, electrical fastigial nucleus stimulation (FNS) has been demonstrated to induce neuroprotection involving multiple mechanisms. In this review, we summarize the protective effects of FNS against cerebral ischemia through the inhibition of electrical activity around the lesion, excitotoxic damage on neurons, and brain inflammatory response, as well as apoptosis. Moreover, FNS has been reported to promote nerve tissue repair, reconstruction, and neurological rehabilitation and improve stroke-related complications including poststroke cognitive dysfunction, depression, and abnormal heart rate variability. We thus further discuss the potential of FNS for clinical applications. Given the absence of any risk of inducing sublethal damage, FNS may offer a new approach to preconditioned neuroprotection against cerebral ischemia.
大约二十年来，电刺激小脑顶核（FNS）已被证明可诱导涉及多种机制的神经保护作用。在本综述中，我们总结了FNS通过抑制损伤周围的电活动、对神经元的兴奋性毒性损伤、脑部炎症反应以及细胞凋亡来对抗脑缺血的保护作用。此外，据报道FNS可促进神经组织修复、重建和神经功能康复，并改善与中风相关的并发症，包括中风后认知功能障碍、抑郁症和异常心率变异性。因此，我们进一步讨论了FNS在临床应用中的潜力。鉴于不存在诱导亚致死性损伤的任何风险，FNS可能为针对脑缺血的预处理神经保护提供一种新方法。
