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[羟苯磺酸钙、醋酸地塞米松和利多卡因联合用药与己酸泼尼松龙和盐酸丁卡因在治疗痔疮中的有效性和安全性比较-]

[Effectiveness and innocuousness of the association of calcium dobesilate, dexamethasone acetate and lidocaine versus prednisolone capronate with dibucaine clorohydrate in the treatment of hemorrhoids-].

作者信息

Marsicano L J, Pérez M, Urquiola G

机构信息

Servicio de Gastroenterologia, Hospital Vargas De Caracas.

出版信息

G E N. 1995 Oct-Dec;49(4):296-302.

PMID:8762660
Abstract

The objective of the present study was to compare properties of two associations in the topical treatment of hemorrhoids. They were included 40 patient with diagnosis of internal hemorrhoids grade 1 or 2, which was indicated topic treatment after the realization of an interrogatory and anoscopy. The treatment received according to a randomized and double blind design: A = dobesilate of calcium with acetato of dexamethasone and lidocaine or B = Capronato of Prednisolone with Clorhidrato of dibucaina, applied twice a day. They were carried out controls every 7 days. In each control was carried out interrogatory and respective anoscopy. There was a prevalence of the females, and the age corresponded to the 5t decade of the life. Patients of the treatment. A presented greater number of predisponents factors, but minor percentage of previous treatments. As for the evaluation of the punctuation of symptoms and of the grade of Hemorrhoids, comparing beginning and final, they didn't show significant difference interproduct confirming the effectiveness and similar inocuity. In both products was observed a important improvement concerning to the symptoms and grade of hemorrhoids but the patients of the treatment A precipitated the greater speed. As for the evaluation made by the phisicians, the treatment A (88%) and B (85.7%) the got successful outputs. The opinion of the patients was a 100% of marked goods or moderated beneficial. Both treatments were successful so much in effectiveness like in inocuity although the treatment A were always got the best efectiveness outputs.

摘要

本研究的目的是比较两种药物组合在痔疮局部治疗中的特性。纳入了40例诊断为1级或2级内痔的患者,在进行问诊和肛门镜检查后进行局部治疗。治疗采用随机双盲设计:A组 = 葡萄糖酸多贝斯与地塞米松醋酸酯和利多卡因;B组 = 泼尼松龙己二酸盐与丁卡因盐酸盐,每天应用两次。每7天进行一次对照检查。每次对照检查时都进行问诊和相应的肛门镜检查。女性患病率较高,年龄对应于生命的第5个十年。治疗A组的患者有更多的易感因素,但既往治疗的比例较小。至于症状评分和痔疮分级的评估,比较开始和结束时,两种治疗产品之间没有显示出显著差异,证实了其有效性和相似的安全性。在两种产品中,关于痔疮症状和分级都观察到了重要改善,但治疗A组的患者速度更快。至于医生的评估,治疗A组(88%)和B组(85.7%)都取得了成功结果。患者的意见是100%为显著改善或中度有益。两种治疗在有效性和安全性方面都很成功,尽管治疗A组总是取得最佳的有效性结果。

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