Argilés J M, López-Soriano F J
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Spain.
Trends Pharmacol Sci. 1996 Jun;17(6):223-6. doi: 10.1016/0165-6147(96)10021-3.
It is generally accepted that muscle wasting is caused by an increase in protein breakdown which seems to be associated with an ATP-dependent, non-lysosomal proteolytic system based on conjugation of proteins to the small polypeptide ubiquitin. Increases in ubiquitin conjugates and in ubiquitin mRNAs are found in the skeletal muscle of experimental animals with various pathological conditions such as infection, acidosis or cancer cachexia. In this review, Josep Argilés and Francisco López-Soriano discuss the role of the ubiquitin-dependent proteolytic pathway in muscle weight loss in pathological situations.
人们普遍认为，肌肉萎缩是由蛋白质分解增加引起的，这似乎与一种基于蛋白质与小多肽泛素结合的ATP依赖性、非溶酶体蛋白水解系统有关。在患有各种病理状况（如感染、酸中毒或癌症恶病质）的实验动物的骨骼肌中，发现泛素缀合物和泛素mRNA增加。在这篇综述中，何塞普·阿吉莱斯和弗朗西斯科·洛佩斯-索里亚诺讨论了泛素依赖性蛋白水解途径在病理情况下肌肉重量减轻中的作用。
