Samonte R V, Ramesh K H, Verma R S
Division of Genetics, Long Island College Hospital, SUNY Health Science Center at Brooklyn, NY 11201, USA.
Genetica. 1996 Jul;98(1):111-3. doi: 10.1007/BF00120226.
We hybridized a human M-BCR DNA probe to the chromosomes of chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla) and orangutan (Pongo pygmaeus) by FISH-technique. The human M-BCR gene was localized to chromosome 23 band q11 (23q11), which is equivalent to the human chromosome 22 band q11 in all three species. The conservation of M-BCR gene in higher primates at the corresponding human chromosome locus provides phylogenetic clues concerning the evolution of genes.
我们通过荧光原位杂交技术,将人类M-BCR DNA探针与黑猩猩(Pan troglodytes)、大猩猩(Gorilla gorilla)和红毛猩猩(Pongo pygmaeus)的染色体进行杂交。人类M-BCR基因定位于23号染色体q11带(23q11),在这三个物种中,该位置相当于人类22号染色体q11带。高等灵长类动物中M-BCR基因在相应人类染色体位点上的保守性,为基因进化提供了系统发育线索。