Nowak D, Zieba M, Zawiasa D, Rozniecki J, Król M
Dept of Pneumonology and Allergology, Medical University of Lódź, Poland.
Monaldi Arch Chest Dis. 1996 Jun;51(3):188-93.
During lower respiratory tract infection, massive influx and activation of phagocytes is observed. Reactive oxygen species (ROS) released by macrophages and polymorphonuclear neutrophils (PMNs) kill microorganisms and cause damage to host tissues. One feature of this damage may be enhanced lipid peroxidation. Therefore, the aim of this study was to estimate the serum concentration of lipid peroxidation products in combination with clinical and biochemical indicators of inflammation in 32 patients with pneumonia. Serum concentration of lipid peroxides (CLP) and malondialdehyde (CMDA) was measured at Day 1, 4, 10 and 14 of observation, whilst chest radiography and routine blood analysis were performed at Day 1 and 14 during a 2 week treatment of lower airway infection. The CLP decreased during treatment (p < 0.05) from 0.059 +/- 0.024 to 0.043 +/- 0.017 (A532 nm) and the CMDA (p < 0.05) from 3.5 +/- 1.4 to 2.8 +/- 1.3 nmol.mL-1. A negative correlation between CLP and radiological regression (r = 0.49) and a drop in white blood cell count (WBC) (r = 0.39) was observed during the treatment. A positive correlation between CMDA and serum trypsin inhibitory capacity (STIC) (r = 0.47) and erythrocyte sedimentation rate (ESR) (r = 0.43) was found. Our data indicate that an enhanced process of lipid peroxidation occurs during pneumonia and that serum concentration of lipid peroxides returns to normal values quicker than the concentration of malondialdehyde during recovery. The use of antioxidants is suggested as an adjuvant treatment in patients with pneumonia.
在下呼吸道感染期间，可观察到吞噬细胞大量涌入并被激活。巨噬细胞和多形核中性粒细胞（PMN）释放的活性氧（ROS）可杀死微生物并对宿主组织造成损伤。这种损伤的一个特征可能是脂质过氧化增强。因此，本研究的目的是结合32例肺炎患者的临床和炎症生化指标，评估脂质过氧化产物的血清浓度。在观察的第1、4、10和14天测量脂质过氧化物（CLP）和丙二醛（CMDA）的血清浓度，同时在为期2周的下呼吸道感染治疗期间的第1天和第14天进行胸部X线摄影和血常规分析。治疗期间CLP从0.059±0.024降至0.043±0.017（A532nm）（p<0.05），CMDA从3.5±1.4降至2.8±1.3nmol·mL-1（p<0.05）。治疗期间观察到CLP与放射学改善（r=0.49）以及白细胞计数（WBC）下降（r=0.39）之间呈负相关。发现CMDA与血清胰蛋白酶抑制能力（STIC）（r=0.47）和红细胞沉降率（ESR）（r=0.43）之间呈正相关。我们的数据表明，肺炎期间脂质过氧化过程增强，且恢复过程中脂质过氧化物的血清浓度比丙二醛浓度更快恢复到正常值。建议在肺炎患者中使用抗氧化剂作为辅助治疗。
