Kesah C N, Coker A O, Alabi S A, Olukoya D K
Department of Medical Microbiology and Parasitology College of Medicine University of Lagos.
Cent Afr J Med. 1996 May;42(5):147-50.
To determine the prevalence, antimicrobial properties and beta-lactamase production of haemolytic enterobacteria in patients with diarrhoea and urinary tract infections in Lagos, Nigeria.
Hospital based prospective study.
Total of 324 patients comprising 194 diarrhoeal and 130 urinary tract infection (UTI) cases.
Production of haemolysms. beta-lactamase and antibiograms of isolates.
186 (57.41 pc) of the 324 clinical specimens screened were positive for enterobacteria, out of which 29 (15.59 pc) were haemolytic. Proteus vulgaris (2.78 pc) Klebsiella spp. (1.85pc). Escherichia coli (1.23 pc). Pseudomonas spp. (0.93 pc). Yersinia enterocolitics and Morganella morganii (0.62 pc). Salmonella spp. Vibrio cholerae and Proteus mirabilis (0.31pc) were the haemolytic enterobacteria Isolated. The susceptibilities of haemolytic bacteria to eight antibotics determined by disc-agar diffusion technique revealed that all 29 (100 pc) haemolytic isolates were sensitive to gentamycin and streptomycin but showed varied susceptibilities to the other drugs. Eleven (37.9 pc) of the 29 isolates produced beta-lactamase.
We conclude that gentamycin and streptomycin are effective drugs against haemolytic isolates from diarrhoea and UTI cases.
确定尼日利亚拉各斯腹泻和尿路感染患者中溶血性肠杆菌的患病率、抗菌特性及β-内酰胺酶产生情况。
基于医院的前瞻性研究。
共324例患者，包括194例腹泻患者和130例尿路感染（UTI）患者。
分离株的溶血、β-内酰胺酶产生情况及抗菌谱。
在筛查的324份临床标本中，186份（57.41%）肠杆菌检测呈阳性，其中29份（15.59%）为溶血性。分离出的溶血性肠杆菌包括普通变形杆菌（2.78%）、克雷伯菌属（1.85%）、大肠杆菌（1.23%）、假单胞菌属（0.93%）、小肠结肠炎耶尔森菌和摩根摩根菌（0.62%）、沙门菌属、霍乱弧菌和奇异变形杆菌（0.31%）。通过纸片琼脂扩散技术测定的29株溶血性细菌对8种抗生素的敏感性显示，所有29株（100%）溶血性分离株对庆大霉素和链霉素敏感，但对其他药物的敏感性各不相同。29株分离株中有11株（37.9%）产生β-内酰胺酶。
我们得出结论，庆大霉素和链霉素是治疗腹泻和UTI病例中溶血性分离株的有效药物。
