van den Burg P J, Hospers J E, van Vliet M, Mosterd W L, Bouma B N, Huisveld I A
Department of Medical Physiology and Sports Medicine, Janus Jongbloed Research Centre (JJRC), University of Utrecht, The Netherlands.
Thromb Haemost. 1995 Dec;74(6):1457-64.
We studied exercise-induced changes in coagulation and fibrinolytic factors and activation products in different age categories. Thirty-eight sedentary males, divided in three age categories (cats I-III; 20-30, 35-45 and 50-60 y) were subjected to a standardized exercise test. Pre-exercise levels (cats I-III resp) of FVII:c (105 +/- 5, 121 +/- 6 and 123 +/- 7% NP), fibrinogen (2.35 +/- 0.12, 2.55 +/- 0.10 and 2.66 +/- 0.09 mg/ml), prothrombin activation fragment F1 + 2 (0.80 +/- 0.10, 0.80 +/- 0.11 and 1.22 +/- 0.16 nM), t-PA (5.2 +/- 0.6, 9.2 +/- 1.0, 8.6 +/- 1.2 ng/ml) and PAI-I (42.8 +/- 7.5, 67.6 +/- 7.6, 62.2 +/- 10.9 ng/ml) showed differences that seemed related to age. Regression analysis revealed associations with anthropometry (FVII:c, fibrinogen, F1+2, t-PA, PAI-1) rather than with age. Exercise-induced changes in coagulation (increase in von Willebrand factor and FVIII:c and a shortening of APTT) and fibrinolytic potential (increase in t-PA and u-PA) were of comparable magnitude for the three age categories. Hardly any change in F1 + 2 (6%) was observed, while thrombin-antithrombin complexes (93%), plasmin-antiplasmin complexes (79%) and D-dimer (77%) almost doubled during maximal exercise. We conclude that anthropometric differences play a more significant role than age on constitutive levels of haemostatic factors in participants up to 60 years of age. The magnitude of exercise-induced changes is comparable in the age categories under study, and simply super-imposed on constitutive (pre-exercise) levels. Clear evidence for prothrombin activation is lacking, but plasmin formation is enhanced during exercise.
我们研究了不同年龄组运动诱导的凝血和纤溶因子及激活产物的变化。38名久坐不动的男性被分为三个年龄组（I - III组；20 - 30岁、35 - 45岁和50 - 60岁），接受标准化运动测试。运动前FVII:c（分别为I - III组105±5、121±6和123±7%NP）、纤维蛋白原（2.35±0.12、2.55±0.10和2.66±0.09mg/ml）、凝血酶原激活片段F1 + 2（0.80±0.10、0.80±0.11和1.22±0.16nM）、组织型纤溶酶原激活物（t - PA，5.2±0.6、9.2±1.0、8.6±1.2ng/ml）和纤溶酶原激活物抑制剂 - I（PAI - I，42.8±7.5、67.6±7.6、62.2±10.9ng/ml）的水平显示出与年龄相关的差异。回归分析显示与人体测量学（FVII:c、纤维蛋白原、F1 + 2、t - PA、PAI - 1）相关，而非与年龄相关。三个年龄组运动诱导的凝血变化（血管性血友病因子和FVIII:c增加以及活化部分凝血活酶时间缩短）和纤溶潜能（t - PA和尿激酶型纤溶酶原激活物增加）幅度相当。F1 + 2几乎没有变化（6%），而在最大运动期间，凝血酶 - 抗凝血酶复合物（93%）、纤溶酶 - 抗纤溶酶复合物（79%）和D - 二聚体（77%）几乎增加了一倍。我们得出结论，在60岁以下的参与者中，人体测量学差异在止血因子的基础水平上比年龄起更重要的作用。在所研究的年龄组中，运动诱导变化的幅度相当，并且只是叠加在基础（运动前）水平上。缺乏凝血酶原激活的确切证据，但运动期间纤溶酶形成增加。
